Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P

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Veröffentlicht in:	Nature genetics 2022-01, Vol.54 (1), p.18-4
Hauptverfasser:	Hawe, Johann S, Wilson, Rory, Schmid, Katharina T, Zhou, Li, Lakshmanan, Lakshmi Narayanan, Lehne, Benjamin C, Kühnel, Brigitte, Scott, William R, Wielscher, Matthias, Yew, Yik Weng, Baumbach, Clemens, Lee, Dominic P, Marouli, Eirini, Bernard, Manon, Pfeiffer, Liliane, Matías-García, Pamela R, Autio, Matias I, Bourgeois, Stephane, Herder, Christian, Karhunen, Ville, Meitinger, Thomas, Prokisch, Holger, Rathmann, Wolfgang, Roden, Michael, Sebert, Sylvain, Shin, Jean, Strauch, Konstantin, Zhang, Weihua, Tan, Wilson L W, Hauck, Stefanie M, Merl-Pham, Juliane, Grallert, Harald, Barbosa, Eudes G V, Illig, Thomas, Peters, Annette, Paus, Tomas, Pausova, Zdenka, Deloukas, Panos, Foo, Roger S Y, Jarvelin, Marjo-Riitta, Kooner, Jaspal S, Loh, Marie, Heinig, Matthias, Gieger, Christian, Waldenberger, Melanie, Chambers, John C, Ahmadi, Kourosh R, Ainali, Chrysanthi, Barrett, Amy, Bataille, Veronique, Bell, Jordana T, Buil, Alfonso, Dermitzakis, Emmanouil T, Dimas, Antigone S, Durbin, Richard, Glass, Daniel, Grundberg, Elin, Hassanali, Neelam, Hedman, Åsa K, Ingle, Catherine, Knowles, David, Krestyaninova, Maria, Lindgren, Cecilia M, Lowe, Christopher E, McCarthy, Mark I, Meduri, Eshwar, di Meglio, Paola, Min, Josine L, Montgomery, Stephen B, Nestle, Frank O, Nica, Alexandra C, Nisbet, James, O'Rahilly, Stephen, Parts, Leopold, Potter, Simon, Sandling, Johanna, Sekowska, Magdalena, Shin, So-Youn, Small, Kerrin S, Soranzo, Nicole, Spector, Tim D, Surdulescu, Gabriela, Travers, Mary E, Tsaprouni, Loukia, Tsoka, Sophia, Wilk, Alicja, Yang, Tsun-Po, Zondervan, Krina T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Arthritis Asthma Blood pressure Body fat Body mass index Body size CD8 antigen Chromatin Chromosomes CpG islands Deoxyribonucleic acid DNA DNA methylation Fatty acids Gene expression Gene loci Gene mapping Genetic diversity Genomes Hypotheses Immunoprecipitation Lymphocytes Lymphocytes T Metabolism Metabolites Molecular interactions Molecular modelling Nucleotide sequence Phenotypes Phenotypic variations Proteins Quantitative trait loci Rheumatoid arthritis Single-nucleotide polymorphism Zinc finger proteins
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Beschreibung
Zusammenfassung:	We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-02T00969-x