The complement cascade in Alzheimer’s disease: a systematic review and meta-analysis

Genetic evidence implicates a causal role for the complement pathway in Alzheimer’s disease (AD). Since studies have shown inconsistent differences in cerebrospinal fluid (CSF) and peripheral blood complement protein concentrations between AD patients and healthy elderly, this study sought to summar...

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Veröffentlicht in:	Molecular psychiatry 2021-10, Vol.26 (10), p.5532-5541
Hauptverfasser:	Krance, Saffire H., Wu, Che-Yuan, Zou, Yi, Mao, Huiyan, Toufighi, Sina, He, Xueyin, Pakosh, Maureen, Swardfager, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378 692/53 692/53/2421 692/699 82 Aged Alzheimer Disease - genetics Alzheimer's disease Amyloid Behavioral Sciences Biological Psychology Biomarkers C-Reactive Protein Cerebrospinal fluid Clusterin Complement Activation Complement C4 Complement component C1q Complement component C3 Complement component C4 Complement factor B Complement factor H Complement system Development and progression Genetic analysis Health aspects Humans Medicine Medicine & Public Health Membrane attack complex Meta-analysis NAD Neurodegenerative diseases Neurosciences Peripheral blood Pharmacotherapy Physiological aspects Proteins Psychiatry SAP protein Systematic review
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Zusammenfassung:	Genetic evidence implicates a causal role for the complement pathway in Alzheimer’s disease (AD). Since studies have shown inconsistent differences in cerebrospinal fluid (CSF) and peripheral blood complement protein concentrations between AD patients and healthy elderly, this study sought to summarize the clinical data. Original peer-reviewed articles measuring CSF and/or blood concentrations of complement or complement regulator protein concentrations in AD and healthy elderly control (HC) groups were included. Of 2966 records identified, means and standard deviations from 86 studies were summarized as standardized mean differences (SMD) by random effects meta-analyses. In CSF, concentrations of clusterin ( N AD / N HC = 625/577, SMD = 0.53, Z 8 = 8.81, p
ISSN:	1359-4184 1476-5578
DOI:	10.1038/s41380-019-0536-8