Clinical implications of local impedance measurement using the IntellaNav MiFi OI ablation catheter: an ex vivo study

Purpose Clinical implication of local impedance (LI) for radiofrequency (RF) ablation has not been fully established. This study aimed to investigate this point using IntellaNav MiFi OI TM catheter. Methods LI and generator impedance drops (ΔLI and ΔGI) were evaluated in excised porcine hearts ( N =...

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Veröffentlicht in:Journal of interventional cardiac electrophysiology 2022-01, Vol.63 (1), p.185-195
Hauptverfasser: Iwakawa, Hidehiro, Takigawa, Masateru, Goya, Masahiko, Iwata, Toyoto, Martin, Claire A., Anzai, Tatsuhiko, Takahashi, Kunihiko, Amemiya, Miki, Yamamoto, Tasuku, Sekigawa, Masahiro, Shirai, Yasuhiro, Tao, Susumu, Hayashi, Tatsuya, Takahashi, Yoshihide, Watanabe, Hiroyuki, Sasano, Tetsuo
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container_end_page 195
container_issue 1
container_start_page 185
container_title Journal of interventional cardiac electrophysiology
container_volume 63
creator Iwakawa, Hidehiro
Takigawa, Masateru
Goya, Masahiko
Iwata, Toyoto
Martin, Claire A.
Anzai, Tatsuhiko
Takahashi, Kunihiko
Amemiya, Miki
Yamamoto, Tasuku
Sekigawa, Masahiro
Shirai, Yasuhiro
Tao, Susumu
Hayashi, Tatsuya
Takahashi, Yoshihide
Watanabe, Hiroyuki
Sasano, Tetsuo
description Purpose Clinical implication of local impedance (LI) for radiofrequency (RF) ablation has not been fully established. This study aimed to investigate this point using IntellaNav MiFi OI TM catheter. Methods LI and generator impedance drops (ΔLI and ΔGI) were evaluated in excised porcine hearts ( N = 16) during RF applications at a range of powers (30 and 50 W), contact forces (5–40 g), and durations (10–180 s) using perpendicular or parallel catheter orientation. Additionally, temporal LI changes were assessed. Results Of the 240 lesions without steam pops (92.3%), ΔLI showed better correlations with lesion surface area ( ρ  = 0.55 vs 0.36,  P = 0.004), maximum depth ( ρ = 0.53 vs 0.14,  P < 0.001), and lesion volume ( ρ = 0.64 vs 0.23,  P < 0.001) than ΔGI. Furthermore, %LI-drop (ΔLI/initial LI) demonstrated stronger correlations with lesion surface area ( ρ = 0.60 vs 0.55, P < 0.001), maximum depth ( ρ = 0.57 vs 0.53, P < 0.001), and volume ( ρ = 0.69 vs 0.64, P < 0.001) than ΔLI. Parallel catheter orientation improved correlation of ΔLI with lesion surface area ( ρ = 0.63 vs 0.40,  P = 0.015) and depth ( ρ = 0.68 vs 0.45,  P = 0.008) and created a larger surface lesion (36.3[29.2–42.7] mm 2 vs 28.8[21.6–34.2] mm 2 , P < 0.001) than the perpendicular. LI of the lesions significantly differed between baseline, immediately after RF, and 5 min after ( P < 0.01). LI reaching plateau, larger initial LI, ΔLI, and %LI-drop, and larger RF power and longer duration were observed in pop lesions ( P < 0.05). Conclusions %LI-drop demonstrated a better correlation with lesion size than ΔLI. LI may be used as an additional parameter to predict lesion size and steam pops. Temporal variation and catheter orientation should be considered to interpret LI.
doi_str_mv 10.1007/s10840-021-00954-8
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This study aimed to investigate this point using IntellaNav MiFi OI TM catheter. Methods LI and generator impedance drops (ΔLI and ΔGI) were evaluated in excised porcine hearts ( N = 16) during RF applications at a range of powers (30 and 50 W), contact forces (5–40 g), and durations (10–180 s) using perpendicular or parallel catheter orientation. Additionally, temporal LI changes were assessed. Results Of the 240 lesions without steam pops (92.3%), ΔLI showed better correlations with lesion surface area ( ρ  = 0.55 vs 0.36,  P = 0.004), maximum depth ( ρ = 0.53 vs 0.14,  P < 0.001), and lesion volume ( ρ = 0.64 vs 0.23,  P < 0.001) than ΔGI. Furthermore, %LI-drop (ΔLI/initial LI) demonstrated stronger correlations with lesion surface area ( ρ = 0.60 vs 0.55, P < 0.001), maximum depth ( ρ = 0.57 vs 0.53, P < 0.001), and volume ( ρ = 0.69 vs 0.64, P < 0.001) than ΔLI. Parallel catheter orientation improved correlation of ΔLI with lesion surface area ( ρ = 0.63 vs 0.40,  P = 0.015) and depth ( ρ = 0.68 vs 0.45,  P = 0.008) and created a larger surface lesion (36.3[29.2–42.7] mm 2 vs 28.8[21.6–34.2] mm 2 , P < 0.001) than the perpendicular. LI of the lesions significantly differed between baseline, immediately after RF, and 5 min after ( P < 0.01). LI reaching plateau, larger initial LI, ΔLI, and %LI-drop, and larger RF power and longer duration were observed in pop lesions ( P < 0.05). Conclusions %LI-drop demonstrated a better correlation with lesion size than ΔLI. LI may be used as an additional parameter to predict lesion size and steam pops. Temporal variation and catheter orientation should be considered to interpret LI.]]></description><identifier>ISSN: 1383-875X</identifier><identifier>EISSN: 1572-8595</identifier><identifier>DOI: 10.1007/s10840-021-00954-8</identifier><identifier>PMID: 33616879</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Ablation ; Animals ; Cardiology ; Catheter Ablation ; Catheters ; Contact force ; Correlation ; Electric Impedance ; Impedance ; Impedance measurement ; Lesions ; Medical instruments ; Medicine ; Medicine &amp; Public Health ; Orientation ; Radio frequency ; Steam ; Surface area ; Swine ; Temporal variations ; Therapeutic Irrigation</subject><ispartof>Journal of interventional cardiac electrophysiology, 2022-01, Vol.63 (1), p.185-195</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. 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This study aimed to investigate this point using IntellaNav MiFi OI TM catheter. Methods LI and generator impedance drops (ΔLI and ΔGI) were evaluated in excised porcine hearts ( N = 16) during RF applications at a range of powers (30 and 50 W), contact forces (5–40 g), and durations (10–180 s) using perpendicular or parallel catheter orientation. Additionally, temporal LI changes were assessed. Results Of the 240 lesions without steam pops (92.3%), ΔLI showed better correlations with lesion surface area ( ρ  = 0.55 vs 0.36,  P = 0.004), maximum depth ( ρ = 0.53 vs 0.14,  P < 0.001), and lesion volume ( ρ = 0.64 vs 0.23,  P < 0.001) than ΔGI. Furthermore, %LI-drop (ΔLI/initial LI) demonstrated stronger correlations with lesion surface area ( ρ = 0.60 vs 0.55, P < 0.001), maximum depth ( ρ = 0.57 vs 0.53, P < 0.001), and volume ( ρ = 0.69 vs 0.64, P < 0.001) than ΔLI. Parallel catheter orientation improved correlation of ΔLI with lesion surface area ( ρ = 0.63 vs 0.40,  P = 0.015) and depth ( ρ = 0.68 vs 0.45,  P = 0.008) and created a larger surface lesion (36.3[29.2–42.7] mm 2 vs 28.8[21.6–34.2] mm 2 , P < 0.001) than the perpendicular. LI of the lesions significantly differed between baseline, immediately after RF, and 5 min after ( P < 0.01). LI reaching plateau, larger initial LI, ΔLI, and %LI-drop, and larger RF power and longer duration were observed in pop lesions ( P < 0.05). Conclusions %LI-drop demonstrated a better correlation with lesion size than ΔLI. LI may be used as an additional parameter to predict lesion size and steam pops. Temporal variation and catheter orientation should be considered to interpret LI.]]></description><subject>Ablation</subject><subject>Animals</subject><subject>Cardiology</subject><subject>Catheter Ablation</subject><subject>Catheters</subject><subject>Contact force</subject><subject>Correlation</subject><subject>Electric Impedance</subject><subject>Impedance</subject><subject>Impedance measurement</subject><subject>Lesions</subject><subject>Medical instruments</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Orientation</subject><subject>Radio frequency</subject><subject>Steam</subject><subject>Surface area</subject><subject>Swine</subject><subject>Temporal variations</subject><subject>Therapeutic Irrigation</subject><issn>1383-875X</issn><issn>1572-8595</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMtOwzAQRS0E4v0DLJAl1gE_E4cdqnhUAroBiZ3lOBMwSpxiJxX9e0xbYMfKI8-ZM5qL0Akl55SQ4iJSogTJCKMZIaUUmdpC-1QWLFOylNup5opnqpAve-ggxneSKMLyXbTHeU5zVZT7aJy0zjtrWuy6eZuKwfU-4r7Bbb_5hdp4C7gDE8cAHfgBj9H5Vzy8AZ76AdrWPJoFfnA3Ds-m2FTtyoKT7A0GCJfYeAyfeOEWPY7DWC-P0E5j2gjHm_cQPd9cP03usvvZ7XRydZ9ZIeiQKWEt2LJh1ArKSgqG5rISrJbCFrSpCGdVXtREGFMTqCSRFFSZUwks3VkpfojO1t556D9GiIN-78fg00rNcloSmXNeJoqtKRv6GAM0eh5cZ8JSU6K_k9brpHVKWq-S1t_q0416rDqof0d-ok0AXwMxtfwrhL_d_2i_AHc6ia4</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Iwakawa, Hidehiro</creator><creator>Takigawa, Masateru</creator><creator>Goya, Masahiko</creator><creator>Iwata, Toyoto</creator><creator>Martin, Claire A.</creator><creator>Anzai, Tatsuhiko</creator><creator>Takahashi, Kunihiko</creator><creator>Amemiya, Miki</creator><creator>Yamamoto, Tasuku</creator><creator>Sekigawa, Masahiro</creator><creator>Shirai, Yasuhiro</creator><creator>Tao, Susumu</creator><creator>Hayashi, Tatsuya</creator><creator>Takahashi, Yoshihide</creator><creator>Watanabe, Hiroyuki</creator><creator>Sasano, Tetsuo</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-8473-7514</orcidid></search><sort><creationdate>20220101</creationdate><title>Clinical implications of local impedance measurement using the IntellaNav MiFi OI ablation catheter: an ex vivo study</title><author>Iwakawa, Hidehiro ; 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This study aimed to investigate this point using IntellaNav MiFi OI TM catheter. Methods LI and generator impedance drops (ΔLI and ΔGI) were evaluated in excised porcine hearts ( N = 16) during RF applications at a range of powers (30 and 50 W), contact forces (5–40 g), and durations (10–180 s) using perpendicular or parallel catheter orientation. Additionally, temporal LI changes were assessed. Results Of the 240 lesions without steam pops (92.3%), ΔLI showed better correlations with lesion surface area ( ρ  = 0.55 vs 0.36,  P = 0.004), maximum depth ( ρ = 0.53 vs 0.14,  P < 0.001), and lesion volume ( ρ = 0.64 vs 0.23,  P < 0.001) than ΔGI. Furthermore, %LI-drop (ΔLI/initial LI) demonstrated stronger correlations with lesion surface area ( ρ = 0.60 vs 0.55, P < 0.001), maximum depth ( ρ = 0.57 vs 0.53, P < 0.001), and volume ( ρ = 0.69 vs 0.64, P < 0.001) than ΔLI. Parallel catheter orientation improved correlation of ΔLI with lesion surface area ( ρ = 0.63 vs 0.40,  P = 0.015) and depth ( ρ = 0.68 vs 0.45,  P = 0.008) and created a larger surface lesion (36.3[29.2–42.7] mm 2 vs 28.8[21.6–34.2] mm 2 , P < 0.001) than the perpendicular. LI of the lesions significantly differed between baseline, immediately after RF, and 5 min after ( P < 0.01). LI reaching plateau, larger initial LI, ΔLI, and %LI-drop, and larger RF power and longer duration were observed in pop lesions ( P < 0.05). Conclusions %LI-drop demonstrated a better correlation with lesion size than ΔLI. LI may be used as an additional parameter to predict lesion size and steam pops. Temporal variation and catheter orientation should be considered to interpret LI.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>33616879</pmid><doi>10.1007/s10840-021-00954-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8473-7514</orcidid></addata></record>
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subjects Ablation
Animals
Cardiology
Catheter Ablation
Catheters
Contact force
Correlation
Electric Impedance
Impedance
Impedance measurement
Lesions
Medical instruments
Medicine
Medicine & Public Health
Orientation
Radio frequency
Steam
Surface area
Swine
Temporal variations
Therapeutic Irrigation
title Clinical implications of local impedance measurement using the IntellaNav MiFi OI ablation catheter: an ex vivo study
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