Mechanochemistry Enabled Construction of Isoxazole Skeleton via CuO Nanoparticles Catalyzed Intermolecular Dehydrohalogenative Annulation
A dehydrohalogenative approach for isoxazole annulation by partnering β‐vinyl halides and α‐nitrocarbonyls under mechanochemical setting was accomplished. This chemistry is operative under the cooperative catalysis of cupric oxide nanoparticles (
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| Veröffentlicht in: | Advanced synthesis & catalysis 2021-11, Vol.363 (21), p.4941-4952 |
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| container_issue | 21 |
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| container_title | Advanced synthesis & catalysis |
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| creator | Vadivelu, Murugan Sampath, Sugirdha Muthu, Kesavan Karthikeyan, Kesavan Praveen, Chandrasekar |
| description | A dehydrohalogenative approach for isoxazole annulation by partnering β‐vinyl halides and α‐nitrocarbonyls under mechanochemical setting was accomplished. This chemistry is operative under the cooperative catalysis of cupric oxide nanoparticles ( |
| doi_str_mv | 10.1002/adsc.202100730 |
| format | Article |
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This chemistry is operative under the cooperative catalysis of cupric oxide nanoparticles (<50 nm) and DABCO. The key beneficial aspects of this protocol include: (i) broad substrate scope, (ii) no vigorous work‐up, (iii) short reaction time, (iv) solvent‐free condition, (v) commercial viability of substrates/reagents (vi) good chemical yields and selectivity. The other merit of this chemistry is the ease with which CuO can be recuperated and reused after the reaction with not much drop in catalytic activity for six runs. 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| subjects | Alkynes Catalysis Catalytic activity Chemical reactions Copper oxides CuO nanocatalysis Dehydrohalogenative annulation Halides Isoxazoles Mechanochemistry Nanoparticles Organic chemistry Reaction time Reagents Selectivity Solvent-free conditions Substrates |
| title | Mechanochemistry Enabled Construction of Isoxazole Skeleton via CuO Nanoparticles Catalyzed Intermolecular Dehydrohalogenative Annulation |
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