Synthesis and biological evaluation of some 3H-quinazolin-4-one derivatives

Synthesis and biological evaluation of some 3H-quinazolin-4-one derivatives

Starting from 3-phenylquinazoline-2,4(1 H ,3 H )-dithione, some new derivatives of 3 H -quinazoline-4-ones were synthesized. The structures of all new compounds were inferred based on the mass spectral, infrared, and NMR spectral data as well as the elemental analytical data. Some compounds were cho...

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Veröffentlicht in:Journal of the Iranian Chemical Society 2022, Vol.19 (1), p.291-302
Hauptverfasser: Sharaf, Afrah, Ragab, Sherif Shaban, Elbarbary, Ahmed A., Shaban, Elkhabiry, El Sayed, Ibrahim El Tantawy
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Anticancer properties
Biochemistry
Chemical synthesis
Chemistry
Chemistry and Materials Science
Fungicides
Infrared analysis
Inorganic Chemistry
NMR
Nuclear magnetic resonance
Organic Chemistry
Original Paper
Physical Chemistry
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Zusammenfassung:Starting from 3-phenylquinazoline-2,4(1 H ,3 H )-dithione, some new derivatives of 3 H -quinazoline-4-ones were synthesized. The structures of all new compounds were inferred based on the mass spectral, infrared, and NMR spectral data as well as the elemental analytical data. Some compounds were chosen for testing their biological activities as antibacterial, antifungal, and anticancer agents. Graphic abstract
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-021-02315-8