How Climate Scenarios Lost Touch With Reality

The integrity of science depends on its capacity to provide an ever more reliable picture of how the world works. Over the past decade or so, serious threats to this integrity have come to light. The expectation that science is inherently self-correcting, and that it moves cumulatively and progressively away from false beliefs and toward truth, has been challenged in numerous fields--including cancer research, neuroscience, hydrology, cosmology, and economics--as observers discover that many published findings are of poor quality, subject to systemic biases, or irreproducible. In a particularly troubling example from the biomedical sciences, a 2015 literature review found that almost 900 peer-reviewed publications reporting studies of a supposed breast cancer cell line were in fact based on a misidentified skin cancer line. Worse still, nearly 250 of these studies were published even after the mistaken cell line was conclusively identified in 2007. A cursory search of Google Scholar indicates that researchers are still using the skin cancer cell line in breast cancer studies published in 2021. All of these erroneous studies remain in the literature and will continue to be a source of misinformation for scientists working on breast cancer.