Electrochemical oxidative cyclization of N -allylcarboxamides: efficient synthesis of halogenated oxazolines

Herein, we reported an efficient and sustainable intramolecular electrochemical cyclization of N -allylcarboxamides for the synthesis of various halogenated oxazolines. This method was conducted in a simple undivided cell by employing lithium halogen salts as redox media and halogen sources. A wide range of oxazolines, including five- and six-membered heterocycles, and iodo-, bromo-, and chloro-methyl oxazolines were constructed in moderate to good yields at room temperature. Notably, this electrochemical oxidative cyclization obviates the use of external oxidants.