Vascular remodelling after treatment with intravitreal anti‐vascular endothelial growth factor in patients with neovascular age‐related macular degeneration

Purpose Age‐related macular degeneration /AMD/ is a progressive, degenerative disease, involving the central retina. It is among leading causes for blindness worldwide. It is subdivided into three forms: “dry” /atrophic/, exudative and neovascular /nAMD/. Neovascular form is characterized by the presence of choroidal neovascularization /CNV/. The aim of our study is to evaluate the effect of treatment of nAMD with intravitreal anti‐vascular endothelial growth factor /anti‐VEGF/. Methods We performed a full ophthalmic examination /best corrected visual acuity for distance and near, tonometry, biomicroscopy, ophthalmoscopy and optic coherence tomography – angiography OCT‐A/ of 152 patients with nAMD. After full examination and evaluation, patients were treated with intravitreal anti‐VEGF, according to protocol – 3 loading doses every 40 days. Results We subdivided the patients in different groups, according to morphologic characteristics of their neovascular membranes, based on OCT‐A. Conclusions The morphologic type of neovascular membrane on OCT‐A is strongly related to the responce and effect of treatment.