Regio‐ and Stereoselective Functionalization Enabled by Bidentate Directing Groups

Chelation‐assisted C−H bond and alkene functionalization using bidentate directing groups offers an elegant and versatile approach to overcome regiocontrol issues by allowing the catalyst to come into close proximity with the targeted sites. In this personal account, we highlight our recent works in developing regio‐ and stereocontrolled functionalizations through transition‐metal catalysis enabled by bidentate directing groups. We classify our results into two categories: (1) regioselective alkene functionalization using bidentate directing groups, and (2) asymmetric C–H functionalization using chiral bidentate directing groups. Furthermore, density functional theory studies to elucidate the origin of the regio‐ and stereoselectivity exerted by bidentate directing groups are discussed. This personal account focuses on the recent development of regioselective alkene functionalization through transition‐metal catalysis enabled by bidentate directing groups. Asymmetric C−H functionalization using chiral bidentate directing groups is also highlighted.