Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles

Herein, we report a series of 1,2,3-triazole combined with quinazoline hybrid heterocyclic compounds by 1,3-dipolar cycloaddition reaction catalyzed by Cu(I). This reaction has been carried out between quinazoline based alkyne and aryl/benzyl azides under optimized conditions. Modification of 4-hydroxyquinazoline by propargyl bromide in presence of potassium carbonate gives a corresponding alkyne. Structure of the synthesized compounds has been characterized by IR, 1 H, and 13 C NMR, ESI-Mass, and HRMS spectra. The products have been tested for anticancer activity against C6 glioma cell lines and characterized by moderate cytotoxic activity.