Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis

This trial compared the oral HIF-PHI daprodustat with conventional erythropoiesis-stimulating agents for the treatment of anemia in patients with chronic kidney disease receiving dialysis. Daprodustat was noninferior to ESAs regarding the change in the hemoglobin level from baseline and cardiovascul...

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Veröffentlicht in:	The New England journal of medicine 2021-12, Vol.385 (25), p.2325-2335
Hauptverfasser:	Singh, Ajay K, Carroll, Kevin, Perkovic, Vlado, Solomon, Scott, Jha, Vivekanand, Johansen, Kirsten L, Lopes, Renato D, Macdougall, Iain C, Obrador, Gregorio T, Waikar, Sushrut S, Wanner, Christoph, Wheeler, David C, Więcek, Andrzej, Blackorby, Allison, Cizman, Borut, Cobitz, Alexander R, Davies, Rich, Dole, Jo, Kler, Lata, Meadowcroft, Amy M, Zhu, Xinyi, McMurray, John J.V
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anemia Anemia - drug therapy Anemia - etiology Barbiturates - adverse effects Barbiturates - therapeutic use Cardiology Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Cerebral infarction Chronic Kidney Disease Clinical trials Coronary Disease Coronaviruses COVID-19 Darbepoetin alfa - adverse effects Darbepoetin alfa - therapeutic use Epoetin Alfa - adverse effects Epoetin Alfa - therapeutic use Erythropoiesis Erythropoietin Female Glycine - adverse effects Glycine - analogs & derivatives Glycine - therapeutic use Heart attacks Hematinics - adverse effects Hematinics - therapeutic use Hematology Hemodialysis Hemoglobin Hemoglobins - analysis Humans Hydroxylase Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors Hypoxia-inducible factors Intention to Treat Analysis Iron Kidney diseases Kidney Replacement Therapy Male Middle Aged Myocardial Infarction Myocardial Infarction - epidemiology Nephrology Oncology Oncology General Patients Peritoneal dialysis Prolyl hydroxylase Renal Dialysis Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Software Statistical analysis Stroke - epidemiology
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Beschreibung
Zusammenfassung:	This trial compared the oral HIF-PHI daprodustat with conventional erythropoiesis-stimulating agents for the treatment of anemia in patients with chronic kidney disease receiving dialysis. Daprodustat was noninferior to ESAs regarding the change in the hemoglobin level from baseline and cardiovascular outcomes.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2113379