A Practical Synthesis of N‐aryl/N‐alkyl 4‐Pyridones under Continuous Flow Technology

In this report, a practical synthetic approach to access N‐aryl/N‐alkyl 4‐pyridones via a two‐step continuous flow process has been developed. In comparison to batch conditions, this [3+2+1] cycloaddition involving a three‐components cascade reaction of aniline, dialkyl ethoxymethyl enemalonate and dialkyl acetylenedicarboxylate under mild conditions, which can provide N‐aryl/N‐alkyl 4‐pyridone derivatives with a wider substrate scope and good to excellent yields. In this report, a practical approach to access polysubstituted N‐aryl 4‐pyridones via a two‐step continuous flow process under mild conditions has been developed. In comparison to batch conditions, this [3+2+1] cycloaddition involving a three‐components cascade reaction of aniline, dialkyl ethoxymethyl enemalonate and dialkyl acetylenedicarboxylate, which can provide various polysubstituted N‐aryl 4‐pyridone derivatives with a wider substrate scope and good to excellent yields.