Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones

We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl 4 -induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2021-12, Vol.172 (2), p.133-136
Hauptverfasser:	Tursunova, N. V., Syrov, V. N., Khushbaktova, Z. A., Tornuev, Yu. V., Klinnikova, M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Outbred Strains Benzo(a)pyrene Benzo(a)pyrene hydroxylase Biomedical and Life Sciences Biomedicine Biotransformation Carbon tetrachloride Cell Biology Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Cytochrome Cytochrome c Cytochrome P-450 Cytochrome P-450 Enzyme System - metabolism Cytoprotection - drug effects Hepatitis Hydroxylase Internal Medicine Laboratory Medicine Lactones Lactones - pharmacology Lactones - therapeutic use Liver Liver - drug effects Liver - metabolism Male Metabolism Metabolites Microsomes Microsomes, Liver - drug effects Microsomes, Liver - enzymology Microsomes, Liver - metabolism Mixed Function Oxygenases - metabolism Monooxygenase NADPH-diaphorase Nitric oxide Nitric Oxide - metabolism Nitrite reductase Pathology Physiological aspects Phytochemicals - pharmacology Rats Sesquiterpene lactones Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Toxic hepatitis
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Zusammenfassung:	We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl 4 -induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-021-05349-3