Binuclear Complexes of Cu(II) and Mg(II) with 2-Furancarboxylic Acid: Synthesis, Structure, EPR Spectroscopy, and Results of In Vitro Biological Activity against Mycolicibacterium Smegmatis and SCOV3

Using the reactions of copper(II) acetate magnesium(II) oxide with 2-furancarboxylic acid (HFur), compounds with chemical compositions [Cu 2 (Fur) 4 (MeCN) 2 ] ( I ) and [Mg 2 (Fur) 4 (H 2 O) 5 ]∙ MeCN∙H 2 O ( II ) are synthesized. According to the X-ray diffraction data (CIF files CCDC nos. 2085817 ( I ) and 2085818 ( II )), both complexes have a binuclear structure. The metal core of I correspond to the tetracarboxylate bridged {Cu 2 (μ-Fur) 4 } complex, the coordination number of the copper atom in which is 5 (CuNO 4 ); in II , the metal atoms are linked by two carboxylate groups and a water molecule, and the coordination environment of the metal centers is completed to the polyhedron (MgO 6 ) by oxygen atoms of the Fur – anions and water molecules. According to EPR spectroscopy data, exchange-coupled copper(II) dimers with a substantial zero-field splitting are observed in I . For I and II , antibacterial activity against the nonpathogenic strain of M. smegmatis , and cytotoxicity against human ovarian adenocarcinoma cells SCOV3 and normal human fibroblast cells of the HDF line have been determined.