Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules

Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules

We demonstrate here that DNA-binding small molecules stabilize hairpin structures formed in short tandem repeat sequences, leading to efficient contractions of repeats during in vitro DNA synthesis. Repeat contraction by synthetic small molecules shows a repeat-number and sequence selective manner.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry letters 2021-11, Vol.50 (11), p.1848-1851
Hauptverfasser: Hagihara, Masaki, Dohno, Chikara, Saito, Kaoru, Sugimoto, Kazuhiro, Hishinuma, Yuta, Sohma, Yuri, Shibata, Tomonori, Nakatani, Kazuhiko
Format: Artikel
Sprache:eng
Schlagworte:
Binding
Chemical synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We demonstrate here that DNA-binding small molecules stabilize hairpin structures formed in short tandem repeat sequences, leading to efficient contractions of repeats during in vitro DNA synthesis. Repeat contraction by synthetic small molecules shows a repeat-number and sequence selective manner.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.210415