Invasive Candidiasis in Liver Transplant Recipients: A Review

Purpose of Review This review summarizes the literature on invasive candidiasis (IC) in liver transplant recipients (LTRs) regarding diagnostic strategies, treatment, and prophylaxis. Recent Findings Recent literature on IC has expanded and refined definitions of risk factors for IC in LTRs. We disc...

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Veröffentlicht in:Current fungal infection reports 2021-12, Vol.15 (4), p.151-161
Hauptverfasser: Sigler, Rachel, Aslam, Saima
Format: Artikel
Sprache:eng
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Zusammenfassung:Purpose of Review This review summarizes the literature on invasive candidiasis (IC) in liver transplant recipients (LTRs) regarding diagnostic strategies, treatment, and prophylaxis. Recent Findings Recent literature on IC has expanded and refined definitions of risk factors for IC in LTRs. We discuss increasing rates of resistance among candida species and new antifungals. Diagnostic modalities continue to decrease time to initiation of empiric antifungals, which may impact outcomes. Summary A well-documented host of risk factors for IC may allow for targeted prophylaxis, while minimizing exposure to antifungal medications. Further research on minimum effective duration of treatment and prophylaxis is needed to combat resistance.
ISSN:1936-3761
1936-377X
DOI:10.1007/s12281-021-00426-6