A Catellani and retro -Diels–Alder strategy to access 1-amino phenanthrenes via ortho - and interannular C–H activation of 2-iodobiphenyls

An efficient palladium-catalyzed three-component domino reaction of 2-iodobiphenyls, O -benzoylhydroxylamines, and norbornadiene has been developed to construct diverse 1-amino phenanthrene derivatives. The methodology realizes simultaneous construction of one C–N bond and two C–C bonds via a Catellani and retro -Diels–Alder strategy by ortho - and interannular C–H activation of 2-iodobiphenyls. Furthermore, this methodology features good functional group tolerance and broad substrate scope.