Incidence, predictors and clinical impact of permanent pacemaker insertion in women following transcatheter aortic valve implantation: Insights from a prospective multinational registry

Objectives To describe the incidence, predictors, and clinical impact of permanent pacemaker insertion (PPI) following transcatheter aortic valve replacement (TAVR) in women. Background Data on pacemaker insertion complicating TAVR in women are scarce. Methods The Women's International Transcatheter Aortic Valve implantation (WIN‐TAVI) is a prospective registry evaluating the safety and efficacy of TAVR in women. We included patients without preprocedural pacemakers and divided them into two groups: (1) PPI and (2) no‐PPI. We identified PPI predictors using logistic regression and studied its clinical impact on the Valve Academic Research Consortium (VARC)‐2 efficacy and safety endpoints. Results Out of 1019 patients, 922 were included in the analysis. Post‐TAVR PPI occurred in 132 (14.3%) patients. Clinical and procedural characteristics were similar in both groups. Pre‐existing right bundle branch block (RBBB) was associated with a high risk of post‐TAVR PPI (OR 3.62, 95% CI 1.85–7.06, p