Synthesis and characterization of a novel and reusable Fe3O4@THAM-CH2CH2-SCH2CO2H magnetic nanocatalyst for highly efficient preparation of xanthenes and 3-aminoisoxazoles in green conditions

In the present study, the synthesis and catalytic application of a novel thioglycolic acid doped on Fe 3 O 4 nanomagnetic particles coated with tris(hydroxymethyl)aminomethane (THAM) and 1,2-dichloroethane are described. The morphology, structure, and physicochemical properties have elucidated by several analytical methods like FT-IR, TEM, VSM, XRD, TGA, and FE-SEM. This nanocatalyst has successfully applied as a heterogeneous acid catalyst in the synthesis of diversely substituted biologically important xanthene and 3-aminoisoxazole derivatives. This catalyst eliminates our need for long-time reaction and hard catalyst separation from product, and it can be easily recovered with an external magnet for eight consecutive times without a significant decrease in its catalytic properties. Graphic abstract