P209 Treatable traits in diagnosis-naïve and untreated patients with suspected asthma – data from the RADICA study
BackgroundThe identification of treatable traits (TT) has been proposed as a means to facilitate the delivery of precision medicine in severe asthma. We hypothesise that a similar approach may also provide novel insights in symptomatic patients during initial diagnosis, and aimed to evaluate the pre...
Gespeichert in:
| Veröffentlicht in: | Thorax 2021-11, Vol.76 (Suppl 2), p.A180-A181 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | A181 |
|---|---|
| container_issue | Suppl 2 |
| container_start_page | A180 |
| container_title | Thorax |
| container_volume | 76 |
| creator | Wang, R Choudhury, I Healy, L Drake, S Willmore, L Mitchelle, J Tudge, R Simpson, A Murray, CS Fowler, SJ |
| description | BackgroundThe identification of treatable traits (TT) has been proposed as a means to facilitate the delivery of precision medicine in severe asthma. We hypothesise that a similar approach may also provide novel insights in symptomatic patients during initial diagnosis, and aimed to evaluate the prevalence of TT in those with and without subsequently-confirmed asthma.MethodSymptomatic yet untreated patients with clinician-suspected asthma were recruited. Clinical history and examination were carried out before spirometry with bronchodilator reversibility (BDR), fractional exhaled nitric oxide, and bronchial challenges were performed. Blood eosinophils were measured and patients were skin prick tested. An asthma diagnosis was confirmed or refuted following 6–8 weeks of inhaled corticosteroids (ICS). Medication adherence was recorded using INhaler Compliance Assessment (INCA) device.ResultsOf 81 adults (≥16 years), 12 were excluded as ‘unclassifiable’ due to borderline results or missing data. Of the remainder, 42 (45% male, mean [SD] 32.0 [12.3] yrs) were diagnosed with asthma and 27 (25% male, 37.1 [12.5] yrs) were not. Pulmonary, extrapulmonary and psychosocial TT were identified in both asthma and non-asthma patients (table 1). Whilst airflow limitation, BDR, airway inflammation and bronchial hyperresponsiveness were more prevalent in asthma than non-asthma, exercise-induced symptoms were equally prevalent in both groups, as were extrapulmonary features such as obesity, rhinitis and atopy. There were more current smokers in asthma (21.4%) compared to non-asthma (7.7%, p |
| doi_str_mv | 10.1136/thorax-2021-BTSabstracts.318 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_bmj_j</sourceid><recordid>TN_cdi_proquest_journals_2594960522</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2594960522</sourcerecordid><originalsourceid>FETCH-LOGICAL-b1318-45437ec5f51440f4dd24baa8bc3f3dd0959ffee2763a1b6e92e9a258cf2eac693</originalsourceid><addsrcrecordid>eNpNkEtOwzAQhi0EEqVwB0uwNfgVJ16W8pQqgaCso0nskFRtUmKHwq4bTsBBOAQ36UlwVCRYjTT69P8zH0InjJ4yJtSZL5sW3ginnJHz6SNkzreQe3cqWLKDBkyqhAiu1S4aUCopUSJW--jAuRmlNGEsHqDVPad6s_6YthY8ZHOLQ0TlHa5qbCp4rhtXOVLD99erxVAb3NW-R63BS_CVrQO6qnyJXeeWNu_34Hy5ALxZf2ITMnHRNgvsS4sfRhe34xF2vjPvh2ivgLmzR79ziJ6uLqfjGzK5uw7QhGQsPEFkJEVs86iImJS0kMZwmQEkWS4KYQzVkS4Ka3msBLBMWc2tBh4lecEt5EqLITre5i7b5qWzzqezpmvrUJnySEutaMR5oJItlS1mfwCjaa853WpOe83pf81puFD8AOnGemw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2594960522</pqid></control><display><type>article</type><title>P209 Treatable traits in diagnosis-naïve and untreated patients with suspected asthma – data from the RADICA study</title><source>Alma/SFX Local Collection</source><creator>Wang, R ; Choudhury, I ; Healy, L ; Drake, S ; Willmore, L ; Mitchelle, J ; Tudge, R ; Simpson, A ; Murray, CS ; Fowler, SJ</creator><creatorcontrib>Wang, R ; Choudhury, I ; Healy, L ; Drake, S ; Willmore, L ; Mitchelle, J ; Tudge, R ; Simpson, A ; Murray, CS ; Fowler, SJ</creatorcontrib><description>BackgroundThe identification of treatable traits (TT) has been proposed as a means to facilitate the delivery of precision medicine in severe asthma. We hypothesise that a similar approach may also provide novel insights in symptomatic patients during initial diagnosis, and aimed to evaluate the prevalence of TT in those with and without subsequently-confirmed asthma.MethodSymptomatic yet untreated patients with clinician-suspected asthma were recruited. Clinical history and examination were carried out before spirometry with bronchodilator reversibility (BDR), fractional exhaled nitric oxide, and bronchial challenges were performed. Blood eosinophils were measured and patients were skin prick tested. An asthma diagnosis was confirmed or refuted following 6–8 weeks of inhaled corticosteroids (ICS). Medication adherence was recorded using INhaler Compliance Assessment (INCA) device.ResultsOf 81 adults (≥16 years), 12 were excluded as ‘unclassifiable’ due to borderline results or missing data. Of the remainder, 42 (45% male, mean [SD] 32.0 [12.3] yrs) were diagnosed with asthma and 27 (25% male, 37.1 [12.5] yrs) were not. Pulmonary, extrapulmonary and psychosocial TT were identified in both asthma and non-asthma patients (table 1). Whilst airflow limitation, BDR, airway inflammation and bronchial hyperresponsiveness were more prevalent in asthma than non-asthma, exercise-induced symptoms were equally prevalent in both groups, as were extrapulmonary features such as obesity, rhinitis and atopy. There were more current smokers in asthma (21.4%) compared to non-asthma (7.7%, p<0.05), but psychosocial history and medication compliance during trial of ICS were similar in both groups. Reflux was the most prevalent TT identified in non-asthma (77.8%), found almost twice as commonly as in asthma (40.4%, p=0.005). Although atopy was the single most common feature in asthma (73.8%), the majority of non-asthmatics were also sensitised (55.6%). Four of 15 (26.7%, three with asthma) symptomatic and pet-sensitised patients had ongoing pet exposures.Abstract P209 Table 1Summary of prevalence of treatable traits identified in symptomatic patients Category Treatable traits Asthma Non-asthma p-value Pulmonary Airflow limitation 12/42 (28.6%) 0/27 (0%) 0.006 Bronchodilator reversibility 19/42 (45.2%) 0/27 (0%) <0.001 High FeNO (≥40ppb) 23/42 (54.8%) 3/27 (11.1%) <0.001 Blood eosinophilia (≥0.4 x 109 cells/L) 14/40 (35.0%) 0/25 (0%) 0.002 Exercise induced breathlessness 25/42 (59.5%) 17/27 (63.0%) 0.974 Bronchial hyperresponsiveness to methacholine 19/33 (57.6%) 0/24 (0%) <0.001 Extra pulmonary Symptoms of rhinitis, n(%) 24/42 (57.1%) 18/27(66.7%) 0.590 History of nasal polyps n(%) 1/42 (2.4%) 0/27 (0%) 1.00 Obesity (BMI>30) 14/42 (33.3%) 11/27 (40.7%) 0.713 Symptoms of reflux 17/42 (40.5%) 21/27 (77.8%) 0.005 Eczema 12/42 (28.6%) 3/27 (11.1%) 0.157 Atopy∞ 31/42 (73.8%) 15/27 (55.6%) 0.191 Cat-sensitised 6/42 (14.3%) 5/27 (18.5%) 0.740 Cat-sensitised and exposure 2/6 (33.3%) 1/5 (20%) 1.00 Dog-sensitised 4/42 (9.5%) 0/27 (0%) 0.290 Dog-sensitised and exposure 1/4 (25.0%) 0/0 n/a Self-reported food allergy 4/42 (9.5%) 4/27 (14.8%) 0.776 Psychosocial Current smoker 9/42 (21.4%) 2/27 (7.7%) 0.047 Former smoker 4/42 (9.5%) 8/27 (30.7%) Non smoker 29/42 (69.0%) 16/27 (61.5%) Self-reported anxiety/psychiatric disease 8/42 (19.0%) 9/27 (33.3%) 0.290 Medication compliance rate*,Median (IQR) 78.9(64.4–89.5)% 78.6(67.0–87.0)% 0.149 Data presented as n (%), p-value calculated using chi-squared test or fisher’s exact test. FeNO: fractional exhaled nitric oxide; ∞ Skin prick test to eight common inhaled aeroallergens. *Data presented as median (IQR), p-value calculated using Mann-Whitney U test.ConclusionTreatable traits are common in patients with symptoms of asthma regardless of diagnostic labels, although the patterns of prominent features may be different, suggesting that personalised management strategy could be offered to symptomatic patients both with and without confirmed asthma. Future research should focus on further characterisation of TT in symptomatic patients with uncertain diagnosis.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thorax-2021-BTSabstracts.318</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Asthma ; Asthma: phenotyping and the response to biologics ; Bronchodilators ; Nitric oxide ; Rhinitis</subject><ispartof>Thorax, 2021-11, Vol.76 (Suppl 2), p.A180-A181</ispartof><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Wang, R</creatorcontrib><creatorcontrib>Choudhury, I</creatorcontrib><creatorcontrib>Healy, L</creatorcontrib><creatorcontrib>Drake, S</creatorcontrib><creatorcontrib>Willmore, L</creatorcontrib><creatorcontrib>Mitchelle, J</creatorcontrib><creatorcontrib>Tudge, R</creatorcontrib><creatorcontrib>Simpson, A</creatorcontrib><creatorcontrib>Murray, CS</creatorcontrib><creatorcontrib>Fowler, SJ</creatorcontrib><title>P209 Treatable traits in diagnosis-naïve and untreated patients with suspected asthma – data from the RADICA study</title><title>Thorax</title><addtitle>Thorax</addtitle><description>BackgroundThe identification of treatable traits (TT) has been proposed as a means to facilitate the delivery of precision medicine in severe asthma. We hypothesise that a similar approach may also provide novel insights in symptomatic patients during initial diagnosis, and aimed to evaluate the prevalence of TT in those with and without subsequently-confirmed asthma.MethodSymptomatic yet untreated patients with clinician-suspected asthma were recruited. Clinical history and examination were carried out before spirometry with bronchodilator reversibility (BDR), fractional exhaled nitric oxide, and bronchial challenges were performed. Blood eosinophils were measured and patients were skin prick tested. An asthma diagnosis was confirmed or refuted following 6–8 weeks of inhaled corticosteroids (ICS). Medication adherence was recorded using INhaler Compliance Assessment (INCA) device.ResultsOf 81 adults (≥16 years), 12 were excluded as ‘unclassifiable’ due to borderline results or missing data. Of the remainder, 42 (45% male, mean [SD] 32.0 [12.3] yrs) were diagnosed with asthma and 27 (25% male, 37.1 [12.5] yrs) were not. Pulmonary, extrapulmonary and psychosocial TT were identified in both asthma and non-asthma patients (table 1). Whilst airflow limitation, BDR, airway inflammation and bronchial hyperresponsiveness were more prevalent in asthma than non-asthma, exercise-induced symptoms were equally prevalent in both groups, as were extrapulmonary features such as obesity, rhinitis and atopy. There were more current smokers in asthma (21.4%) compared to non-asthma (7.7%, p<0.05), but psychosocial history and medication compliance during trial of ICS were similar in both groups. Reflux was the most prevalent TT identified in non-asthma (77.8%), found almost twice as commonly as in asthma (40.4%, p=0.005). Although atopy was the single most common feature in asthma (73.8%), the majority of non-asthmatics were also sensitised (55.6%). Four of 15 (26.7%, three with asthma) symptomatic and pet-sensitised patients had ongoing pet exposures.Abstract P209 Table 1Summary of prevalence of treatable traits identified in symptomatic patients Category Treatable traits Asthma Non-asthma p-value Pulmonary Airflow limitation 12/42 (28.6%) 0/27 (0%) 0.006 Bronchodilator reversibility 19/42 (45.2%) 0/27 (0%) <0.001 High FeNO (≥40ppb) 23/42 (54.8%) 3/27 (11.1%) <0.001 Blood eosinophilia (≥0.4 x 109 cells/L) 14/40 (35.0%) 0/25 (0%) 0.002 Exercise induced breathlessness 25/42 (59.5%) 17/27 (63.0%) 0.974 Bronchial hyperresponsiveness to methacholine 19/33 (57.6%) 0/24 (0%) <0.001 Extra pulmonary Symptoms of rhinitis, n(%) 24/42 (57.1%) 18/27(66.7%) 0.590 History of nasal polyps n(%) 1/42 (2.4%) 0/27 (0%) 1.00 Obesity (BMI>30) 14/42 (33.3%) 11/27 (40.7%) 0.713 Symptoms of reflux 17/42 (40.5%) 21/27 (77.8%) 0.005 Eczema 12/42 (28.6%) 3/27 (11.1%) 0.157 Atopy∞ 31/42 (73.8%) 15/27 (55.6%) 0.191 Cat-sensitised 6/42 (14.3%) 5/27 (18.5%) 0.740 Cat-sensitised and exposure 2/6 (33.3%) 1/5 (20%) 1.00 Dog-sensitised 4/42 (9.5%) 0/27 (0%) 0.290 Dog-sensitised and exposure 1/4 (25.0%) 0/0 n/a Self-reported food allergy 4/42 (9.5%) 4/27 (14.8%) 0.776 Psychosocial Current smoker 9/42 (21.4%) 2/27 (7.7%) 0.047 Former smoker 4/42 (9.5%) 8/27 (30.7%) Non smoker 29/42 (69.0%) 16/27 (61.5%) Self-reported anxiety/psychiatric disease 8/42 (19.0%) 9/27 (33.3%) 0.290 Medication compliance rate*,Median (IQR) 78.9(64.4–89.5)% 78.6(67.0–87.0)% 0.149 Data presented as n (%), p-value calculated using chi-squared test or fisher’s exact test. FeNO: fractional exhaled nitric oxide; ∞ Skin prick test to eight common inhaled aeroallergens. *Data presented as median (IQR), p-value calculated using Mann-Whitney U test.ConclusionTreatable traits are common in patients with symptoms of asthma regardless of diagnostic labels, although the patterns of prominent features may be different, suggesting that personalised management strategy could be offered to symptomatic patients both with and without confirmed asthma. Future research should focus on further characterisation of TT in symptomatic patients with uncertain diagnosis.</description><subject>Asthma</subject><subject>Asthma: phenotyping and the response to biologics</subject><subject>Bronchodilators</subject><subject>Nitric oxide</subject><subject>Rhinitis</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpNkEtOwzAQhi0EEqVwB0uwNfgVJ16W8pQqgaCso0nskFRtUmKHwq4bTsBBOAQ36UlwVCRYjTT69P8zH0InjJ4yJtSZL5sW3ginnJHz6SNkzreQe3cqWLKDBkyqhAiu1S4aUCopUSJW--jAuRmlNGEsHqDVPad6s_6YthY8ZHOLQ0TlHa5qbCp4rhtXOVLD99erxVAb3NW-R63BS_CVrQO6qnyJXeeWNu_34Hy5ALxZf2ITMnHRNgvsS4sfRhe34xF2vjPvh2ivgLmzR79ziJ6uLqfjGzK5uw7QhGQsPEFkJEVs86iImJS0kMZwmQEkWS4KYQzVkS4Ka3msBLBMWc2tBh4lecEt5EqLITre5i7b5qWzzqezpmvrUJnySEutaMR5oJItlS1mfwCjaa853WpOe83pf81puFD8AOnGemw</recordid><startdate>20211108</startdate><enddate>20211108</enddate><creator>Wang, R</creator><creator>Choudhury, I</creator><creator>Healy, L</creator><creator>Drake, S</creator><creator>Willmore, L</creator><creator>Mitchelle, J</creator><creator>Tudge, R</creator><creator>Simpson, A</creator><creator>Murray, CS</creator><creator>Fowler, SJ</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20211108</creationdate><title>P209 Treatable traits in diagnosis-naïve and untreated patients with suspected asthma – data from the RADICA study</title><author>Wang, R ; Choudhury, I ; Healy, L ; Drake, S ; Willmore, L ; Mitchelle, J ; Tudge, R ; Simpson, A ; Murray, CS ; Fowler, SJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1318-45437ec5f51440f4dd24baa8bc3f3dd0959ffee2763a1b6e92e9a258cf2eac693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Asthma</topic><topic>Asthma: phenotyping and the response to biologics</topic><topic>Bronchodilators</topic><topic>Nitric oxide</topic><topic>Rhinitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, R</creatorcontrib><creatorcontrib>Choudhury, I</creatorcontrib><creatorcontrib>Healy, L</creatorcontrib><creatorcontrib>Drake, S</creatorcontrib><creatorcontrib>Willmore, L</creatorcontrib><creatorcontrib>Mitchelle, J</creatorcontrib><creatorcontrib>Tudge, R</creatorcontrib><creatorcontrib>Simpson, A</creatorcontrib><creatorcontrib>Murray, CS</creatorcontrib><creatorcontrib>Fowler, SJ</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, R</au><au>Choudhury, I</au><au>Healy, L</au><au>Drake, S</au><au>Willmore, L</au><au>Mitchelle, J</au><au>Tudge, R</au><au>Simpson, A</au><au>Murray, CS</au><au>Fowler, SJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P209 Treatable traits in diagnosis-naïve and untreated patients with suspected asthma – data from the RADICA study</atitle><jtitle>Thorax</jtitle><stitle>Thorax</stitle><date>2021-11-08</date><risdate>2021</risdate><volume>76</volume><issue>Suppl 2</issue><spage>A180</spage><epage>A181</epage><pages>A180-A181</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><abstract>BackgroundThe identification of treatable traits (TT) has been proposed as a means to facilitate the delivery of precision medicine in severe asthma. We hypothesise that a similar approach may also provide novel insights in symptomatic patients during initial diagnosis, and aimed to evaluate the prevalence of TT in those with and without subsequently-confirmed asthma.MethodSymptomatic yet untreated patients with clinician-suspected asthma were recruited. Clinical history and examination were carried out before spirometry with bronchodilator reversibility (BDR), fractional exhaled nitric oxide, and bronchial challenges were performed. Blood eosinophils were measured and patients were skin prick tested. An asthma diagnosis was confirmed or refuted following 6–8 weeks of inhaled corticosteroids (ICS). Medication adherence was recorded using INhaler Compliance Assessment (INCA) device.ResultsOf 81 adults (≥16 years), 12 were excluded as ‘unclassifiable’ due to borderline results or missing data. Of the remainder, 42 (45% male, mean [SD] 32.0 [12.3] yrs) were diagnosed with asthma and 27 (25% male, 37.1 [12.5] yrs) were not. Pulmonary, extrapulmonary and psychosocial TT were identified in both asthma and non-asthma patients (table 1). Whilst airflow limitation, BDR, airway inflammation and bronchial hyperresponsiveness were more prevalent in asthma than non-asthma, exercise-induced symptoms were equally prevalent in both groups, as were extrapulmonary features such as obesity, rhinitis and atopy. There were more current smokers in asthma (21.4%) compared to non-asthma (7.7%, p<0.05), but psychosocial history and medication compliance during trial of ICS were similar in both groups. Reflux was the most prevalent TT identified in non-asthma (77.8%), found almost twice as commonly as in asthma (40.4%, p=0.005). Although atopy was the single most common feature in asthma (73.8%), the majority of non-asthmatics were also sensitised (55.6%). Four of 15 (26.7%, three with asthma) symptomatic and pet-sensitised patients had ongoing pet exposures.Abstract P209 Table 1Summary of prevalence of treatable traits identified in symptomatic patients Category Treatable traits Asthma Non-asthma p-value Pulmonary Airflow limitation 12/42 (28.6%) 0/27 (0%) 0.006 Bronchodilator reversibility 19/42 (45.2%) 0/27 (0%) <0.001 High FeNO (≥40ppb) 23/42 (54.8%) 3/27 (11.1%) <0.001 Blood eosinophilia (≥0.4 x 109 cells/L) 14/40 (35.0%) 0/25 (0%) 0.002 Exercise induced breathlessness 25/42 (59.5%) 17/27 (63.0%) 0.974 Bronchial hyperresponsiveness to methacholine 19/33 (57.6%) 0/24 (0%) <0.001 Extra pulmonary Symptoms of rhinitis, n(%) 24/42 (57.1%) 18/27(66.7%) 0.590 History of nasal polyps n(%) 1/42 (2.4%) 0/27 (0%) 1.00 Obesity (BMI>30) 14/42 (33.3%) 11/27 (40.7%) 0.713 Symptoms of reflux 17/42 (40.5%) 21/27 (77.8%) 0.005 Eczema 12/42 (28.6%) 3/27 (11.1%) 0.157 Atopy∞ 31/42 (73.8%) 15/27 (55.6%) 0.191 Cat-sensitised 6/42 (14.3%) 5/27 (18.5%) 0.740 Cat-sensitised and exposure 2/6 (33.3%) 1/5 (20%) 1.00 Dog-sensitised 4/42 (9.5%) 0/27 (0%) 0.290 Dog-sensitised and exposure 1/4 (25.0%) 0/0 n/a Self-reported food allergy 4/42 (9.5%) 4/27 (14.8%) 0.776 Psychosocial Current smoker 9/42 (21.4%) 2/27 (7.7%) 0.047 Former smoker 4/42 (9.5%) 8/27 (30.7%) Non smoker 29/42 (69.0%) 16/27 (61.5%) Self-reported anxiety/psychiatric disease 8/42 (19.0%) 9/27 (33.3%) 0.290 Medication compliance rate*,Median (IQR) 78.9(64.4–89.5)% 78.6(67.0–87.0)% 0.149 Data presented as n (%), p-value calculated using chi-squared test or fisher’s exact test. FeNO: fractional exhaled nitric oxide; ∞ Skin prick test to eight common inhaled aeroallergens. *Data presented as median (IQR), p-value calculated using Mann-Whitney U test.ConclusionTreatable traits are common in patients with symptoms of asthma regardless of diagnostic labels, although the patterns of prominent features may be different, suggesting that personalised management strategy could be offered to symptomatic patients both with and without confirmed asthma. Future research should focus on further characterisation of TT in symptomatic patients with uncertain diagnosis.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><doi>10.1136/thorax-2021-BTSabstracts.318</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0040-6376 |
| ispartof | Thorax, 2021-11, Vol.76 (Suppl 2), p.A180-A181 |
| issn | 0040-6376 1468-3296 |
| language | eng |
| recordid | cdi_proquest_journals_2594960522 |
| source | Alma/SFX Local Collection |
| subjects | Asthma Asthma: phenotyping and the response to biologics Bronchodilators Nitric oxide Rhinitis |
| title | P209 Treatable traits in diagnosis-naïve and untreated patients with suspected asthma – data from the RADICA study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T12%3A53%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_bmj_j&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=P209%E2%80%85Treatable%20traits%20in%20diagnosis-na%C3%AFve%20and%20untreated%20patients%20with%20suspected%20asthma%20%E2%80%93%20data%20from%20the%20RADICA%20study&rft.jtitle=Thorax&rft.au=Wang,%20R&rft.date=2021-11-08&rft.volume=76&rft.issue=Suppl%202&rft.spage=A180&rft.epage=A181&rft.pages=A180-A181&rft.issn=0040-6376&rft.eissn=1468-3296&rft_id=info:doi/10.1136/thorax-2021-BTSabstracts.318&rft_dat=%3Cproquest_bmj_j%3E2594960522%3C/proquest_bmj_j%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2594960522&rft_id=info:pmid/&rfr_iscdi=true |