P209 Treatable traits in diagnosis-naïve and untreated patients with suspected asthma – data from the RADICA study

BackgroundThe identification of treatable traits (TT) has been proposed as a means to facilitate the delivery of precision medicine in severe asthma. We hypothesise that a similar approach may also provide novel insights in symptomatic patients during initial diagnosis, and aimed to evaluate the prevalence of TT in those with and without subsequently-confirmed asthma.MethodSymptomatic yet untreated patients with clinician-suspected asthma were recruited. Clinical history and examination were carried out before spirometry with bronchodilator reversibility (BDR), fractional exhaled nitric oxide, and bronchial challenges were performed. Blood eosinophils were measured and patients were skin prick tested. An asthma diagnosis was confirmed or refuted following 6–8 weeks of inhaled corticosteroids (ICS). Medication adherence was recorded using INhaler Compliance Assessment (INCA) device.ResultsOf 81 adults (≥16 years), 12 were excluded as ‘unclassifiable’ due to borderline results or missing data. Of the remainder, 42 (45% male, mean [SD] 32.0 [12.3] yrs) were diagnosed with asthma and 27 (25% male, 37.1 [12.5] yrs) were not. Pulmonary, extrapulmonary and psychosocial TT were identified in both asthma and non-asthma patients (table 1). Whilst airflow limitation, BDR, airway inflammation and bronchial hyperresponsiveness were more prevalent in asthma than non-asthma, exercise-induced symptoms were equally prevalent in both groups, as were extrapulmonary features such as obesity, rhinitis and atopy. There were more current smokers in asthma (21.4%) compared to non-asthma (7.7%, p