P132 Intermediate follow up of radiological interstitial changes for COVID-19 patients over the first year post discharge: a longitudinal study

IntroductionCOVID-19 follow up has become a high priority, with clear evidence that significant proportions of survivors continue to have symptoms at follow up. It has been demonstrated that 56% of those with severe COVID had lung diffusion (DLCO) impairment and more than 50% had radiographic abnormalities at 6 month follow up.1 However there is limited evidence at present how these abnormalities change over time beyond the first assessment.We present CT imaging results for patients discharged after COVID-19 infection, at various time points over the first year after discharge. Pulmonary function tests for this cohort are currently being analysed.Methods387 COVID-19 patients were followed up post discharge. There are 81 baseline CTs available for analysis, and of these 35 had a repeat CT thorax prior to second assessment based on clinical need.All the CT images were independently assessed by a Thoracic Radiologist using BSTI criteria2 and compared to subsequent CTs for the same patient. A higher proportion of those with PCVCT3 had repeat CT imaging as expected due to clinical need.DiscussionOn repeat assessment, all patients had significantly improved respiratory symptom scores (MRC and CAT score). Only 3 of 35 patients had progressive fibrosis on the second scan, all of whom had PCVCT3 on initial imaging. None of those who had PCVCT1 or 2 on initial imaging went on to develop fibrosis and all showed improvement on subsequent imaging.Abstract P132 Table 1Follow up symptoms and radiological findings at first and second assessment post discharge. Analysed by Wilcoxon Rank Sum, median (range) First timepoint Second timepoint P value Clinic assessment (months post discharge) 1.5 (1–3) 9 (6–12) CT scan (months post discharge) 2.5 (1–4) 8 (6–12) MRC score 3 (2–4) 1 (1–3)