Selectivity of hosts for guests by liquid-assisted grinding: differences between solution and mechanochemistry

Selectivity for particular guests in two host-guest systems has been investigated using both solution-based and mechanochemical methods. Selectivity was shown to occur in both systems when using mechanochemistry. The selectivity profile obtained using mechanochemistry can be different from that observed when carrying out analogous selectivity experiments in solution. Selectivity profiles obtained mechanochemically differ from those obtained in solution, both for selectivity during crystallisation and selectivity by guest exchange.