Bacteria recycle tumour waste to fuel immune cells

Key nutrients that are needed by immune cells are scarce in tumours. Engineered cancer-invading bacteria can recycle tumour waste into metabolic fuel to boost anticancer immune responses in mice. Engineered microbes at a tumour site make nutrients that aid T cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2021-10, Vol.598 (7882), p.570-571
Hauptverfasser:	Chen, Laurence C., Chen, Yvonne Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/67 692/308 Amino acids Ammonia Antibodies Anticancer properties Arginine Bacteria Biosynthesis Cancer Colon Colon cancer Colorectal cancer Genetic engineering Genetic modification Humanities and Social Sciences Immune system Immunological memory Immunotherapy Lymphocytes Lymphocytes T Melanoma Memory cells Metabolism multidisciplinary News And Views Oncology, Experimental PD-L1 protein Physiological aspects Proteins Science Skin cancer T cells Tumors Waste to energy
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Beschreibung
Zusammenfassung:	Key nutrients that are needed by immune cells are scarce in tumours. Engineered cancer-invading bacteria can recycle tumour waste into metabolic fuel to boost anticancer immune responses in mice. Engineered microbes at a tumour site make nutrients that aid T cells.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/d41586-021-02639-8