A comprehensive review of diverse issues related to Sickle cell disease

This review was carried out to understand diverse issues in sickle cell disease (SCD), such as its prevalence, clinical manifestations, preventive measures, secondary infections, nutrition and therapies. The review of literature for diverse issues related to Sickle cell disease (SCD) revealed varied aspects to address the SCD related issues. The prevalence reported by different authors varies significantly that warrants initiation of a comprehensive SCD screening programme. The pathophysiological changes in the patients with SCD present a challenging and dynamic situation, which needs to be studied in more details.