The impact of the artificial sweetener, acesulfame-k, consumption during pregnancy on postpartum maternal metabolic health and adipose tissue biology in a mouse model

The impact of the artificial sweetener, acesulfame-k, consumption during pregnancy on postpartum maternal metabolic health and adipose tissue biology in a mouse model

Body weight and food intake was consistent across all groups throughout pregnancy and PP. Gene expression of Lepr(Leptin receptor) was decreased in the AS group (1.2±0.2 vs 0.4±0.09; P = 0.03) compared to CD and Fasn (Fatty acid synthase) was increased in the AS compared to CD and Fr groups (3.7±0.9...

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Veröffentlicht in:Proceedings of the Nutrition Society 2021, Vol.80 (OCE5), Article E225
Hauptverfasser: Bridge-Comer, P.E., Spada, A., Morton-Jones, J., Vickers, M.H., Reynolds, C.M.
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Adipose tissue
Body fat
Body weight
Diabetes
Fatty acids
Fatty-acid synthase
Food intake
Gene expression
Glucose
Homeostasis
Metabolism
Pregnancy
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Zusammenfassung:Body weight and food intake was consistent across all groups throughout pregnancy and PP. Gene expression of Lepr(Leptin receptor) was decreased in the AS group (1.2±0.2 vs 0.4±0.09; P = 0.03) compared to CD and Fasn (Fatty acid synthase) was increased in the AS compared to CD and Fr groups (3.7±0.9 vs 1.03±0.2, 1.1±0.2; P = 0.02). [...]ASs may not represent beneficial substitutes to fructose during pregnancy, with the potential to induce GDM-like symptoms in the mothers and increase the risk of T2DM in later life in mothers.
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665121003530