Purine adducts as a presumable missing link for aristolochic acid nephropathy‐related cellular energy crisis, potential anti‐fibrotic prevention and treatment

Aristolochic acid nephropathy is a progressive exposome‐induced disease characterized by tubular atrophy and fibrosis culminating in end‐stage renal disease and malignancies. The molecular mechanisms of the energy crisis as a putative cause of fibrosis have not yet been elucidated. In light of the f...

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Veröffentlicht in:British journal of pharmacology 2021-11, Vol.178 (22), p.4411-4427
Hauptverfasser: Kocic, Gordana, Gajic, Mihajlo, Tomovic, Katarina, Hadzi‐Djokic, Jovan, Anderluh, Marko, Smelcerovic, Andrija
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Sprache:eng
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