An efficient and combined placental T1‐ADC acquisition in pregnancies with and without pre‐eclampsia
Purpose To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre‐eclampsia. Methods Slice and diffusion preparation shuffling, bu...
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| Veröffentlicht in: | Magnetic resonance in medicine 2021-11, Vol.86 (5), p.2684-2691 |
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| creator | Hutter, Jana Ho, Alison Jackson, Laurence H. Slator, Paddy J. Chappell, Lucy C. Hajnal, Joseph V. Rutherford, Mary A. |
| description | Purpose
To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre‐eclampsia.
Methods
Slice and diffusion preparation shuffling, built on the previously proposed ZEBRA method, is presented as a robust and fast way to obtain T1 and apparent diffusivity coefficient (ADC) values. Joint modeling and evaluation is performed on a cohort of healthy and pre‐eclamptic participants at 3T.
Results
The datasets show the ability to obtain robust and fast T1‐ADC measurements. Significant decay over gestation in T1 (−11 ms/week, P |
| doi_str_mv | 10.1002/mrm.28809 |
| format | Article |
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To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre‐eclampsia.
Methods
Slice and diffusion preparation shuffling, built on the previously proposed ZEBRA method, is presented as a robust and fast way to obtain T1 and apparent diffusivity coefficient (ADC) values. Joint modeling and evaluation is performed on a cohort of healthy and pre‐eclamptic participants at 3T.
Results
The datasets show the ability to obtain robust and fast T1‐ADC measurements. Significant decay over gestation in T1 (−11 ms/week, P<.05) and a trend toward significance in ADC (−0.23 mm/s2/week, P = .08) values can be observed in a control cohort. Values for the pre‐eclamptic pregnancies show a negative trend for both ADC and T1.
Conclusions
The presented sequence allows the simultaneous acquisition of 2 of the most promising quantitative parameters to study placental insufficiency—identified individually as relevant in previous studies—in under 2 minutes. This allows dynamic assessment of physiological processes, reduced inconsistency in spatial comparisons due to reduced motion artefacts and opens novel avenues for analysis. Initial results in pre‐eclamptic placentas, with depicted changes in both ADC and T1, illustrate its potential to identify cases of placental insufficiency. Future work will focus on expanding the field‐of‐view using multi‐band acceleration techniques and the expansion to larger and more diverse patient groups.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.28809</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>ADC ; diffusion ; Eclampsia ; Parameter identification ; Placenta ; Preeclampsia ; Pregnancy ; quantitative ; relaxometry ; Robustness ; Spatial analysis ; T 1</subject><ispartof>Magnetic resonance in medicine, 2021-11, Vol.86 (5), p.2684-2691</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3476-3500</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.28809$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.28809$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Hutter, Jana</creatorcontrib><creatorcontrib>Ho, Alison</creatorcontrib><creatorcontrib>Jackson, Laurence H.</creatorcontrib><creatorcontrib>Slator, Paddy J.</creatorcontrib><creatorcontrib>Chappell, Lucy C.</creatorcontrib><creatorcontrib>Hajnal, Joseph V.</creatorcontrib><creatorcontrib>Rutherford, Mary A.</creatorcontrib><title>An efficient and combined placental T1‐ADC acquisition in pregnancies with and without pre‐eclampsia</title><title>Magnetic resonance in medicine</title><description>Purpose
To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre‐eclampsia.
Methods
Slice and diffusion preparation shuffling, built on the previously proposed ZEBRA method, is presented as a robust and fast way to obtain T1 and apparent diffusivity coefficient (ADC) values. Joint modeling and evaluation is performed on a cohort of healthy and pre‐eclamptic participants at 3T.
Results
The datasets show the ability to obtain robust and fast T1‐ADC measurements. Significant decay over gestation in T1 (−11 ms/week, P<.05) and a trend toward significance in ADC (−0.23 mm/s2/week, P = .08) values can be observed in a control cohort. Values for the pre‐eclamptic pregnancies show a negative trend for both ADC and T1.
Conclusions
The presented sequence allows the simultaneous acquisition of 2 of the most promising quantitative parameters to study placental insufficiency—identified individually as relevant in previous studies—in under 2 minutes. This allows dynamic assessment of physiological processes, reduced inconsistency in spatial comparisons due to reduced motion artefacts and opens novel avenues for analysis. Initial results in pre‐eclamptic placentas, with depicted changes in both ADC and T1, illustrate its potential to identify cases of placental insufficiency. Future work will focus on expanding the field‐of‐view using multi‐band acceleration techniques and the expansion to larger and more diverse patient groups.</description><subject>ADC</subject><subject>diffusion</subject><subject>Eclampsia</subject><subject>Parameter identification</subject><subject>Placenta</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>quantitative</subject><subject>relaxometry</subject><subject>Robustness</subject><subject>Spatial analysis</subject><subject>T 1</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNotkE1qwzAQhUVpoWnaRW8g6NqJNJJlaxnSX0golHQtZFtqFGzZsWxCdj1Cz9iT1E66msfMe_PgQ-iekhklBOZVW80gTYm8QBMaA0QQS36JJiThJGJU8mt0E8KOECJlwidou_DYWOtyZ3yHtS9wXleZ86bATanzYalLvKG_3z-LxyXW-b53wXWu9th53LTmy2s_ZAM-uG57yo-i7rvxOKRMXuqqCU7foiury2Du_ucUfT4_bZav0er95W25WEUNAJNRLIThlAgbW6GLTMSU6TTlOUjDQIqUZExkmksAS4qMCsIhN5KlkorECGHZFD2c_zZtve9N6NSu7ls_VCqIUxAsoRQG1_zsOrjSHFXTukq3R0WJGimqgaI6UVTrj_VJsD92xGhn</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Hutter, Jana</creator><creator>Ho, Alison</creator><creator>Jackson, Laurence H.</creator><creator>Slator, Paddy J.</creator><creator>Chappell, Lucy C.</creator><creator>Hajnal, Joseph V.</creator><creator>Rutherford, Mary A.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-3476-3500</orcidid></search><sort><creationdate>202111</creationdate><title>An efficient and combined placental T1‐ADC acquisition in pregnancies with and without pre‐eclampsia</title><author>Hutter, Jana ; Ho, Alison ; Jackson, Laurence H. ; Slator, Paddy J. ; Chappell, Lucy C. ; Hajnal, Joseph V. ; Rutherford, Mary A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2239-566e4106f5f6adb6513a884c29e329680b36ba4922f0db16042ce9389167e66f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ADC</topic><topic>diffusion</topic><topic>Eclampsia</topic><topic>Parameter identification</topic><topic>Placenta</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>quantitative</topic><topic>relaxometry</topic><topic>Robustness</topic><topic>Spatial analysis</topic><topic>T 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hutter, Jana</creatorcontrib><creatorcontrib>Ho, Alison</creatorcontrib><creatorcontrib>Jackson, Laurence H.</creatorcontrib><creatorcontrib>Slator, Paddy J.</creatorcontrib><creatorcontrib>Chappell, Lucy C.</creatorcontrib><creatorcontrib>Hajnal, Joseph V.</creatorcontrib><creatorcontrib>Rutherford, Mary A.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hutter, Jana</au><au>Ho, Alison</au><au>Jackson, Laurence H.</au><au>Slator, Paddy J.</au><au>Chappell, Lucy C.</au><au>Hajnal, Joseph V.</au><au>Rutherford, Mary A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An efficient and combined placental T1‐ADC acquisition in pregnancies with and without pre‐eclampsia</atitle><jtitle>Magnetic resonance in medicine</jtitle><date>2021-11</date><risdate>2021</risdate><volume>86</volume><issue>5</issue><spage>2684</spage><epage>2691</epage><pages>2684-2691</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Purpose
To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre‐eclampsia.
Methods
Slice and diffusion preparation shuffling, built on the previously proposed ZEBRA method, is presented as a robust and fast way to obtain T1 and apparent diffusivity coefficient (ADC) values. Joint modeling and evaluation is performed on a cohort of healthy and pre‐eclamptic participants at 3T.
Results
The datasets show the ability to obtain robust and fast T1‐ADC measurements. Significant decay over gestation in T1 (−11 ms/week, P<.05) and a trend toward significance in ADC (−0.23 mm/s2/week, P = .08) values can be observed in a control cohort. Values for the pre‐eclamptic pregnancies show a negative trend for both ADC and T1.
Conclusions
The presented sequence allows the simultaneous acquisition of 2 of the most promising quantitative parameters to study placental insufficiency—identified individually as relevant in previous studies—in under 2 minutes. This allows dynamic assessment of physiological processes, reduced inconsistency in spatial comparisons due to reduced motion artefacts and opens novel avenues for analysis. Initial results in pre‐eclamptic placentas, with depicted changes in both ADC and T1, illustrate its potential to identify cases of placental insufficiency. Future work will focus on expanding the field‐of‐view using multi‐band acceleration techniques and the expansion to larger and more diverse patient groups.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/mrm.28809</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3476-3500</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Magnetic resonance in medicine, 2021-11, Vol.86 (5), p.2684-2691 |
| issn | 0740-3194 1522-2594 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | ADC diffusion Eclampsia Parameter identification Placenta Preeclampsia Pregnancy quantitative relaxometry Robustness Spatial analysis T 1 |
| title | An efficient and combined placental T1‐ADC acquisition in pregnancies with and without pre‐eclampsia |
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