An efficient and combined placental T1‐ADC acquisition in pregnancies with and without pre‐eclampsia

Purpose To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre‐eclampsia. Methods Slice and diffusion preparation shuffling, built on the previously proposed ZEBRA method, is presented as a robust and fast way to obtain T1 and apparent diffusivity coefficient (ADC) values. Joint modeling and evaluation is performed on a cohort of healthy and pre‐eclamptic participants at 3T. Results The datasets show the ability to obtain robust and fast T1‐ADC measurements. Significant decay over gestation in T1 (−11 ms/week, P