Iron Promoted Ring Opening and Ring Closing Cascade (ROCC) Reaction of Ortho‐Carboxy‐Isoxazoles Leading to Isoindolinone Derivatives

An efficient and convenient route for the synthesis of various functionalized 3‐alkylidene isoindolin‐1‐ones is presented. The synthesis involves the ring opening and ring closing cascade (ROCC) reaction of ortho‐carboxy‐isoxazole using Fe/NH4Cl. This is the first report for the synthesis of 3‐alkyl...

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Veröffentlicht in:	European journal of organic chemistry 2021-10, Vol.2021 (37), p.5127-5134
Hauptverfasser:	Gudipati, Ramakrishna, Jayaram, Vankudoth, Raghavulu, Karri, Bhoot, Dinesh, Basavaiah, Keloth, Yennam, Satyanarayana, Behera, Manoranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylidene Ammonium chloride Fe rearrangement Iron Isoindolinones Isoxazoles Natural products Ring opening
Online-Zugang:	Volltext
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