Iron Promoted Ring Opening and Ring Closing Cascade (ROCC) Reaction of Ortho‐Carboxy‐Isoxazoles Leading to Isoindolinone Derivatives

Iron Promoted Ring Opening and Ring Closing Cascade (ROCC) Reaction of Ortho‐Carboxy‐Isoxazoles Leading to Isoindolinone Derivatives

An efficient and convenient route for the synthesis of various functionalized 3‐alkylidene isoindolin‐1‐ones is presented. The synthesis involves the ring opening and ring closing cascade (ROCC) reaction of ortho‐carboxy‐isoxazole using Fe/NH4Cl. This is the first report for the synthesis of 3‐alkyl...

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Veröffentlicht in:European journal of organic chemistry 2021-10, Vol.2021 (37), p.5127-5134
Hauptverfasser: Gudipati, Ramakrishna, Jayaram, Vankudoth, Raghavulu, Karri, Bhoot, Dinesh, Basavaiah, Keloth, Yennam, Satyanarayana, Behera, Manoranjan
Format: Artikel
Sprache:eng
Schlagworte:
Alkylidene
Ammonium chloride
Fe rearrangement
Iron
Isoindolinones
Isoxazoles
Natural products
Ring opening
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Zusammenfassung:An efficient and convenient route for the synthesis of various functionalized 3‐alkylidene isoindolin‐1‐ones is presented. The synthesis involves the ring opening and ring closing cascade (ROCC) reaction of ortho‐carboxy‐isoxazole using Fe/NH4Cl. This is the first report for the synthesis of 3‐alkylidene isoindolin‐1‐one using Fe/NH4Cl. An efficient and convenient route for the synthesis of various functionalized 3‐alkylidene isoindolin‐1‐ones is presented. The synthesis involves the ring opening and ring closing cascade (ROCC) reaction of ortho‐carboxy‐isoxazole using Fe/NH4Cl. This is the first report for the synthesis of 3‐alkylidene isoindolin‐1‐one using Fe/NH4Cl.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202100716