Perspective and prospects of 2D MXenes for smart biosensing

•MXenes are 2-D layered structures of transition metal carbides, nitrides and carbonitrides.•MXenes possess exceptional opto-electronic and surface properties.•MXenes are emerging materials for smart biosensing applications.•MXenes aid early disease diagnosis and management through novel POC testing devices. The success of internet-of-things (IoT)-assisted wearable biomedical electronics demands novel high-performance biosensing prototypes which depend on smart opto-electric-nanosystems. In this direction, 2D MXenes (early transition metal carbides/nitrides) have recently emerged as materials of choice to investigate biosensors of desired performance due to high electro-conductivity, hydrophilicity, and versatile surface chemistry. This letter highlights recent advances and current challenges to project MXenes for next generation biosensing based on unfurled potentials and novel bio-analytical technologies.