The influence of short-term high-altitude acclimatization on cerebral and leg tissue oxygenation post-orthostasis

Purpose Orthostasis at sea level decreases brain tissue oxygenation and increases risk of syncope. High altitude reduces brain and peripheral muscle tissue oxygenation. This study determined the effect of short-term altitude acclimatization on cerebral and peripheral leg tissue oxygenation index (TO...

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Veröffentlicht in:European journal of applied physiology 2021-11, Vol.121 (11), p.3095-3102
Hauptverfasser: Horiuchi, Masahiro, Okazaki, Kazunobu, Asano, Katsumi, Friend, Alexander T., Rossetti, Gabriella M. K., Oliver, Samuel J.
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Sprache:eng
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Zusammenfassung:Purpose Orthostasis at sea level decreases brain tissue oxygenation and increases risk of syncope. High altitude reduces brain and peripheral muscle tissue oxygenation. This study determined the effect of short-term altitude acclimatization on cerebral and peripheral leg tissue oxygenation index (TOI) post-orthostasis. Method Seven lowlanders completed a supine-to-stand maneuver at sea level (450 m) and for 3 consecutive days at high altitude (3776 m). Cardiorespiratory measurements and near-infrared spectroscopy-derived oxygenation of the frontal lobe (cerebral TOI) and vastus lateralis (leg TOI) were measured at supine and 5-min post-orthostasis. Results After orthostasis at sea level, cerebral TOI decreased [mean Δ% (95% confidential interval): − 4.5%, (− 7.5, − 1.5), P   0.05], whereas leg TOI decreased [days 1–3: − 12.0%, (− 18.3, − 5.7); − 12.1%, (− 18.4, − 5.8); − 10.2%, (− 16.5, − 3.9), respectively, all P  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-021-04765-7