Cell‐Membrane‐Derived Nanoparticles with Notch‐1 Suppressor Delivery Promote Hypoxic Cell–Cell Packing and Inhibit Angiogenesis Acting as a Two‐Edged Sword (Adv. Mater. 40/2021)

Cancer Therapy A two‐edged‐sword strategy for anticancer and chondroprotective treatment is approached by combining two key players, as reported by Mi‐Lan Kang, Hak‐Joon Sung, and co‐workers in article number 2101558. Cell‐membrane‐derived nanoparticles (CMNPs) induce hypoxic cell–cell packing seen commonly in cancer growth and chondrogenesis. Notch‐1 suppressor display on CMNPs inhibits angiogenesis efficiently, thereby promoting anticancer growth and prochondrogenesis simultaneously. This study suggests an unprecedented therapeutic strategy for laryngeal cancer which damages cartilage progressively.