Synthesis of Terminal N‐Vinylazoles from Aromatic Aldehydes, DMSO, and Azoles Based DMSO as Terminal Carbon Synthon

Synthesis of Terminal N‐Vinylazoles from Aromatic Aldehydes, DMSO, and Azoles Based DMSO as Terminal Carbon Synthon

A protocol for the synthesis of terminal N‐vinylazoles from aromatic aldehydes, DMSO, and azoles has been reported. In this strategy, DMSO was involved in the construction of the C=C bond as a terminal carbon synthon. Both aromatic aldehydes and azoles could be well tolerated and give the correspond...

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Veröffentlicht in:Advanced synthesis & catalysis 2021-10, Vol.363 (19), p.4621-4626
Hauptverfasser: Nie, Zhiwen, Lv, Huifang, Li, Hui, Su, Miaodong, Yang, Tonglin, Luo, Weiping, Liu, Qiang, Guo, Cancheng
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Aromatic Aldehydes
Azoles
C=C and C−N bonds Formation
Carbon
DMSO
Heterocyclic compounds
Synthesis
Terminal N-vinylazoles
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Zusammenfassung:A protocol for the synthesis of terminal N‐vinylazoles from aromatic aldehydes, DMSO, and azoles has been reported. In this strategy, DMSO was involved in the construction of the C=C bond as a terminal carbon synthon. Both aromatic aldehydes and azoles could be well tolerated and give the corresponding terminal N‐vinylazoles in 52–91% yields. Based on preliminary experiments, a plausible mechanism is proposed.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202100663