Peutz–Jeghers syndrome complicated by gastric‐type cervical mucinous carcinoma and primary peritoneal carcinoma
A 45‐year‐old multiparous woman with a STK11 mutation and a history of Peutz–Jeghers syndrome underwent radical hysterectomy and bilateral salpingo‐oophorectomy for a gastric‐type cervical mucinous carcinoma. Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2021-10, Vol.47 (10), p.3732-3736 |
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| container_issue | 10 |
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| container_title | The journal of obstetrics and gynaecology research |
| container_volume | 47 |
| creator | Kotaka, Saki Kanno, Kiyoshi Yanai, Shiori Omori, Masako Andou, Masaaki |
| description | A 45‐year‐old multiparous woman with a STK11 mutation and a history of Peutz–Jeghers syndrome underwent radical hysterectomy and bilateral salpingo‐oophorectomy for a gastric‐type cervical mucinous carcinoma. Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker levels, and computed tomography showed multiple calcifications in the peritoneum. Peritoneal dissemination was suspected, and a laparoscopic biopsy was performed. Histopathology showed a high‐grade serous carcinoma, and the patient was diagnosed with a metachronous stage IIIC primary peritoneal carcinoma. She had no BRCA1/2 mutation. After chemotherapy with docetaxel, carboplatin, and bevacizumab, she achieved complete remission. |
| doi_str_mv | 10.1111/jog.14944 |
| format | Article |
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Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker levels, and computed tomography showed multiple calcifications in the peritoneum. Peritoneal dissemination was suspected, and a laparoscopic biopsy was performed. Histopathology showed a high‐grade serous carcinoma, and the patient was diagnosed with a metachronous stage IIIC primary peritoneal carcinoma. She had no BRCA1/2 mutation. 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| identifier | ISSN: 1341-8076 |
| ispartof | The journal of obstetrics and gynaecology research, 2021-10, Vol.47 (10), p.3732-3736 |
| issn | 1341-8076 1447-0756 |
| language | eng |
| recordid | cdi_proquest_journals_2578599298 |
| source | Wiley Journals |
| subjects | Bevacizumab Biopsy BRCA1 protein Cancer Carboplatin Cervix Chemotherapy Computed tomography Gastric cancer gastric type high‐grade serous carcinoma Hysterectomy Laparoscopy mucinous carcinoma Mutation Ovariectomy Peritoneum Peutz–Jeghers syndrome primary peritoneal carcinoma Remission Tumor markers |
| title | Peutz–Jeghers syndrome complicated by gastric‐type cervical mucinous carcinoma and primary peritoneal carcinoma |
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