Peutz–Jeghers syndrome complicated by gastric‐type cervical mucinous carcinoma and primary peritoneal carcinoma

A 45‐year‐old multiparous woman with a STK11 mutation and a history of Peutz–Jeghers syndrome underwent radical hysterectomy and bilateral salpingo‐oophorectomy for a gastric‐type cervical mucinous carcinoma. Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker...

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Veröffentlicht in:The journal of obstetrics and gynaecology research 2021-10, Vol.47 (10), p.3732-3736
Hauptverfasser: Kotaka, Saki, Kanno, Kiyoshi, Yanai, Shiori, Omori, Masako, Andou, Masaaki
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Sprache:eng
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Zusammenfassung:A 45‐year‐old multiparous woman with a STK11 mutation and a history of Peutz–Jeghers syndrome underwent radical hysterectomy and bilateral salpingo‐oophorectomy for a gastric‐type cervical mucinous carcinoma. Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker levels, and computed tomography showed multiple calcifications in the peritoneum. Peritoneal dissemination was suspected, and a laparoscopic biopsy was performed. Histopathology showed a high‐grade serous carcinoma, and the patient was diagnosed with a metachronous stage IIIC primary peritoneal carcinoma. She had no BRCA1/2 mutation. After chemotherapy with docetaxel, carboplatin, and bevacizumab, she achieved complete remission.
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.14944