Thioxanthone Synthesis from Benzoic Acid Esters through Directed ortho-Lithiation

Thioxanthone Synthesis from Benzoic Acid Esters through Directed ortho-Lithiation

An efficient synthetic method for thioxanthones from 3-halobenzoic acid esters is disclosed. Directed ortho-lithiation of 3-halobenzoic acid esters and following arylthiolation realized the synthesis of sterically congested 2-(arylthio)-3-halobenzoic acid esters. Diverse thioxanthones were prepared...

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Veröffentlicht in:Chemistry letters 2021-09, Vol.50 (9), p.1624-1627
Hauptverfasser: Kobayashi, Akihiro, Matsuzawa, Tsubasa, Hosoya, Takamitsu, Yoshida, Suguru
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Acids
Benzoic acid
Esters
Synthesis
Thioxanthenone
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container_end_page 1627
container_issue 9
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container_title Chemistry letters
container_volume 50
creator Kobayashi, Akihiro
Matsuzawa, Tsubasa
Hosoya, Takamitsu
Yoshida, Suguru
description An efficient synthetic method for thioxanthones from 3-halobenzoic acid esters is disclosed. Directed ortho-lithiation of 3-halobenzoic acid esters and following arylthiolation realized the synthesis of sterically congested 2-(arylthio)-3-halobenzoic acid esters. Diverse thioxanthones were prepared by subsequent TfOH-mediated cyclization.
doi_str_mv 10.1246/cl.210293
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source Oxford University Press Journals All Titles (1996-Current)
subjects Acids
Benzoic acid
Esters
Synthesis
Thioxanthenone
title Thioxanthone Synthesis from Benzoic Acid Esters through Directed ortho-Lithiation
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