Thioxanthone Synthesis from Benzoic Acid Esters through Directed ortho-Lithiation

An efficient synthetic method for thioxanthones from 3-halobenzoic acid esters is disclosed. Directed ortho-lithiation of 3-halobenzoic acid esters and following arylthiolation realized the synthesis of sterically congested 2-(arylthio)-3-halobenzoic acid esters. Diverse thioxanthones were prepared...

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Veröffentlicht in:	Chemistry letters 2021-09, Vol.50 (9), p.1624-1627
Hauptverfasser:	Kobayashi, Akihiro, Matsuzawa, Tsubasa, Hosoya, Takamitsu, Yoshida, Suguru
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Benzoic acid Esters Synthesis Thioxanthenone
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Beschreibung
Zusammenfassung:	An efficient synthetic method for thioxanthones from 3-halobenzoic acid esters is disclosed. Directed ortho-lithiation of 3-halobenzoic acid esters and following arylthiolation realized the synthesis of sterically congested 2-(arylthio)-3-halobenzoic acid esters. Diverse thioxanthones were prepared by subsequent TfOH-mediated cyclization.
ISSN:	0366-7022 1348-0715
DOI:	10.1246/cl.210293