Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release

Here, we report an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared by thermally induced silane dehydrocoupling and lipid-coating. This robust formulation offers the ability to release an anticancer drug, for up to 2 weeks, in various biological environments; pH 7.4 buffer, cancer cells, and tumor xenograft model. An ultra-long-acting drug-releasable (>2 weeks) nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared using the thermally induced silane dehydrocoupling, an amphiphilic lipid-coating, and is disclosed for the first time.