Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives

Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives

A method was developed for the synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazoles by acylation of amidoximes with acyl chlorides, followed by cyclization of pyrazolyl- O- acylamidoximes into the respective oxadiazoles. Nitration of these products was studied, in combination with nucleophilic su...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2021-08, Vol.57 (7-8), p.828-836
Hauptverfasser: Shkineva, Tatyana K., Vatsadze, Irina A., Khoranyan, Tigran E., Lipilin, Dmitry L., Pivkina, Alla N., Dalinger, Igor L.
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Aromatic compounds
Chemistry
Chemistry and Materials Science
Nitration
Organic Chemistry
Oxadiazoles
Pharmacy
Substitution reactions
Synthesis
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Zusammenfassung:A method was developed for the synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazoles by acylation of amidoximes with acyl chlorides, followed by cyclization of pyrazolyl- O- acylamidoximes into the respective oxadiazoles. Nitration of these products was studied, in combination with nucleophilic substitution reactions in the obtained nitro derivatives.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-021-02987-3