Pruritus in liver disease – pathenogenisis and treatment

Pruritus in liver disease – pathenogenisis and treatment

Pruritus often constitutes a most irritating ailment in patients suffering from chronic liver diseases, especially when cholestasis plays a prominent role. The exact pathogenesis is not entirely recognized. Nevertheless, several mechanisms have been proposed: pruritus connected with a central/periph...

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Veröffentlicht in:Journal of pre-clinical and clinical research 2011, Vol.5 (2), p.47
Hauptverfasser: Michalak, Agata, Hanc, Magdalena, Fatyga, Aleksandra, Skublewska, Aleksandra, Prystupa, Andrzej, Mosiewicz, Jerzy
Format: Review
Sprache:eng
Schlagworte:
Gallbladder diseases
Pathogenesis
Pruritus
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Zusammenfassung:Pruritus often constitutes a most irritating ailment in patients suffering from chronic liver diseases, especially when cholestasis plays a prominent role. The exact pathogenesis is not entirely recognized. Nevertheless, several mechanisms have been proposed: pruritus connected with a central/peripheral origin, itch caused by mast cells’ hyperactivity, or determined by the intrahepatic cholestasis of pregnancy. This article concentrates on the pruritus accompanying advanced liver disorders. Its pathogenesis and treatment are also discussed.
ISSN:1898-2395
1898-7516