Association between serum uric acid and depressive symptoms among people aged 55 years and above in four provinces of China

[Background] There are limited studies on the correlation between serum uric acid levels and depressive symptoms in middle-aged and elderly populations, and the study results are inconsistent. [Objective] This study is designed to investigate the association between serum uric acid levels and depressive symptoms in a middle-aged and elderly population. [Methods] Based on the 2018-2019 baseline data of the Community-based Cohort Study on Nervous System Diseases, a total of 10 212 people aged 55 years and above with complete demographic, lifestyle, depressive symptom score, and serum uric acid data were selected as study subjects. The Geriatric Depression Scale was used to evaluate whether the respondents had depressive symptoms, and fasting serum uric acid levels were tested at the same time. The positive rate of depressive symptoms and the prevalence rate of hyperuricemia in the population by different characteristics were calculated. The association between serum uric acid levels and depressive symptoms was