A comparison of digital chest radiography and Xpert® MTB/RIF in active case finding for tuberculosis
OBJECTIVE: To compare two community screening tests for TB: sputum examination using Xpert® MTB/RIF and chest radiography (CXR).METHOD: Men aged ≥15 years and women aged >45 years living in 96 sub-communes in Ca Mau, Viet Nam, were invited to provide a single sputum specimen that was tested using...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2020-09, Vol.24 (9), p.934-940 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | Nguyen, T. B. P. Nguyen, T. A. Luu, B. K. Le, T. T. O. Nguyen, V. S. Nguyen, K. C. Duong, K. D. Nguyen, H. B. Nguyen, N. L. Fox, G. J. Nguyen, N. V. Marks, G. B. |
| description | OBJECTIVE: To compare two community screening tests for TB: sputum examination using Xpert® MTB/RIF and chest radiography (CXR).METHOD: Men aged ≥15 years and women aged >45 years living in 96 sub-communes in Ca Mau, Viet Nam, were invited to provide
a single sputum specimen that was tested using Xpert. Participants were also invited to attend a nearby location for digital radiography. Participants whose sputum was Xpert MTB-positive or whose CXR was reported as 'consistent with TB´ were requested to provide two further sputum
specimens for culture. The sensitivities of the two tests for detecting TB (defined as sputum culture-positive for Mycobacterium tuberculosis) were compared.RESULTS: There were 72 985 eligible participants, of whom 57 597 (78.9%) participated in Xpert screening,
12 752 (17.5%) had CXR and 11 235 (15.4%) had both tests. We estimated that there were 59 cases of TB, of whom 20 were Xpert MTB-positive (programmatic sensitivity 34.0%) and 47 had CXR reported as 'consistent with TB´ (sensitivity 80.0%, P < 0.0001).CONCLUSION:
In community-wide screening for TB, CXR is more sensitive than a single spontaneously expectorated sputum sample tested using Xpert, but it has a substantially lower participation rate. |
| doi_str_mv | 10.5588/ijtld.19.0764 |
| format | Article |
| fullrecord | <record><control><sourceid>pubtec_proqu</sourceid><recordid>TN_cdi_proquest_journals_2575276101</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ingid>iuatld/ijtld/2020/00000024/00000009/art00010</ingid><sourcerecordid>iuatld/ijtld/2020/00000024/00000009/art00010</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-f807c1220dad8dcf74c480332bc132db69b335dbc8e25b3906d8c6c92e25ec303</originalsourceid><addsrcrecordid>eNp1kc2KFDEUhYMozo8u3UrAjZvqyU-lkizH0dGBEVFGcBdSSaonTXVSJqmB8aHmIXwy012tgmA29wY-zj33XABeYLRiTIgzvymjXWG5QrxrH4FjLDBruCToce0R4Q3lWB6Bk5w3CBGMMX8KjijFrOMdPgbuHJq4nXTyOQYYB2j92hc9QnPrcoFJWx_XSU-391AHC79NLpWfD_DjzZuzL1eX0AeoTfF3DhqdHRx8sD6s4RATLHPvkpnHmH1-Bp4Meszu-aGegq-X724uPjTXn95fXZxfN6a6LM0gEDeYEGS1FdYMvDWtQJSS3mBKbN_JnlJmeyMcYT2VqLPCdEaS-nWGInoKXi-6U4rf57qA2vps3Djq4OKcFWmZ4EQKLir66h90E-cUqjtFGGekpoNwpZqFMinmnNygpuS3Ot0rjNQuf7XPX2GpdvlX_uVBde63zv6hfwdegc8LUGNyoei_U71RftZ7sXq23dXUHWmDVKSeDQnCFGZ1qHWDnseiik5q_UNlvNv67f80F8HFY9VBCu0faQ8NkkqnUmuV-QXOuLKe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2575276101</pqid></control><display><type>article</type><title>A comparison of digital chest radiography and Xpert® MTB/RIF in active case finding for tuberculosis</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Nguyen, T. B. P. ; Nguyen, T. A. ; Luu, B. K. ; Le, T. T. O. ; Nguyen, V. S. ; Nguyen, K. C. ; Duong, K. D. ; Nguyen, H. B. ; Nguyen, N. L. ; Fox, G. J. ; Nguyen, N. V. ; Marks, G. B.</creator><creatorcontrib>Nguyen, T. B. P. ; Nguyen, T. A. ; Luu, B. K. ; Le, T. T. O. ; Nguyen, V. S. ; Nguyen, K. C. ; Duong, K. D. ; Nguyen, H. B. ; Nguyen, N. L. ; Fox, G. J. ; Nguyen, N. V. ; Marks, G. B.</creatorcontrib><description>OBJECTIVE: To compare two community screening tests for TB: sputum examination using Xpert® MTB/RIF and chest radiography (CXR).METHOD: Men aged ≥15 years and women aged >45 years living in 96 sub-communes in Ca Mau, Viet Nam, were invited to provide
a single sputum specimen that was tested using Xpert. Participants were also invited to attend a nearby location for digital radiography. Participants whose sputum was Xpert MTB-positive or whose CXR was reported as 'consistent with TB´ were requested to provide two further sputum
specimens for culture. The sensitivities of the two tests for detecting TB (defined as sputum culture-positive for Mycobacterium tuberculosis) were compared.RESULTS: There were 72 985 eligible participants, of whom 57 597 (78.9%) participated in Xpert screening,
12 752 (17.5%) had CXR and 11 235 (15.4%) had both tests. We estimated that there were 59 cases of TB, of whom 20 were Xpert MTB-positive (programmatic sensitivity 34.0%) and 47 had CXR reported as 'consistent with TB´ (sensitivity 80.0%, P < 0.0001).CONCLUSION:
In community-wide screening for TB, CXR is more sensitive than a single spontaneously expectorated sputum sample tested using Xpert, but it has a substantially lower participation rate.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>DOI: 10.5588/ijtld.19.0764</identifier><identifier>PMID: 33156761</identifier><language>eng</language><publisher>France: International Union Against Tuberculosis and Lung Disease</publisher><subject>Adolescent ; Chest ; Diagnostic ; Female ; Humans ; Male ; Middle Aged ; Mycobacterium tuberculosis ; Radiographic Image Enhancement ; Radiography ; Screening ; Sensitivity ; Sensitivity and Specificity ; Sputum ; Tuberculosis ; Tuberculosis, Pulmonary - diagnostic imaging ; Vietnam</subject><ispartof>The international journal of tuberculosis and lung disease, 2020-09, Vol.24 (9), p.934-940</ispartof><rights>Copyright International Union against Tuberculosis and Lung Disease (IUATLD) Sep 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-f807c1220dad8dcf74c480332bc132db69b335dbc8e25b3906d8c6c92e25ec303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33156761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, T. B. P.</creatorcontrib><creatorcontrib>Nguyen, T. A.</creatorcontrib><creatorcontrib>Luu, B. K.</creatorcontrib><creatorcontrib>Le, T. T. O.</creatorcontrib><creatorcontrib>Nguyen, V. S.</creatorcontrib><creatorcontrib>Nguyen, K. C.</creatorcontrib><creatorcontrib>Duong, K. D.</creatorcontrib><creatorcontrib>Nguyen, H. B.</creatorcontrib><creatorcontrib>Nguyen, N. L.</creatorcontrib><creatorcontrib>Fox, G. J.</creatorcontrib><creatorcontrib>Nguyen, N. V.</creatorcontrib><creatorcontrib>Marks, G. B.</creatorcontrib><title>A comparison of digital chest radiography and Xpert® MTB/RIF in active case finding for tuberculosis</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>OBJECTIVE: To compare two community screening tests for TB: sputum examination using Xpert® MTB/RIF and chest radiography (CXR).METHOD: Men aged ≥15 years and women aged >45 years living in 96 sub-communes in Ca Mau, Viet Nam, were invited to provide
a single sputum specimen that was tested using Xpert. Participants were also invited to attend a nearby location for digital radiography. Participants whose sputum was Xpert MTB-positive or whose CXR was reported as 'consistent with TB´ were requested to provide two further sputum
specimens for culture. The sensitivities of the two tests for detecting TB (defined as sputum culture-positive for Mycobacterium tuberculosis) were compared.RESULTS: There were 72 985 eligible participants, of whom 57 597 (78.9%) participated in Xpert screening,
12 752 (17.5%) had CXR and 11 235 (15.4%) had both tests. We estimated that there were 59 cases of TB, of whom 20 were Xpert MTB-positive (programmatic sensitivity 34.0%) and 47 had CXR reported as 'consistent with TB´ (sensitivity 80.0%, P < 0.0001).CONCLUSION:
In community-wide screening for TB, CXR is more sensitive than a single spontaneously expectorated sputum sample tested using Xpert, but it has a substantially lower participation rate.</description><subject>Adolescent</subject><subject>Chest</subject><subject>Diagnostic</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>Radiographic Image Enhancement</subject><subject>Radiography</subject><subject>Screening</subject><subject>Sensitivity</subject><subject>Sensitivity and Specificity</subject><subject>Sputum</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - diagnostic imaging</subject><subject>Vietnam</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc2KFDEUhYMozo8u3UrAjZvqyU-lkizH0dGBEVFGcBdSSaonTXVSJqmB8aHmIXwy012tgmA29wY-zj33XABeYLRiTIgzvymjXWG5QrxrH4FjLDBruCToce0R4Q3lWB6Bk5w3CBGMMX8KjijFrOMdPgbuHJq4nXTyOQYYB2j92hc9QnPrcoFJWx_XSU-391AHC79NLpWfD_DjzZuzL1eX0AeoTfF3DhqdHRx8sD6s4RATLHPvkpnHmH1-Bp4Meszu-aGegq-X724uPjTXn95fXZxfN6a6LM0gEDeYEGS1FdYMvDWtQJSS3mBKbN_JnlJmeyMcYT2VqLPCdEaS-nWGInoKXi-6U4rf57qA2vps3Djq4OKcFWmZ4EQKLir66h90E-cUqjtFGGekpoNwpZqFMinmnNygpuS3Ot0rjNQuf7XPX2GpdvlX_uVBde63zv6hfwdegc8LUGNyoei_U71RftZ7sXq23dXUHWmDVKSeDQnCFGZ1qHWDnseiik5q_UNlvNv67f80F8HFY9VBCu0faQ8NkkqnUmuV-QXOuLKe</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Nguyen, T. B. P.</creator><creator>Nguyen, T. A.</creator><creator>Luu, B. K.</creator><creator>Le, T. T. O.</creator><creator>Nguyen, V. S.</creator><creator>Nguyen, K. C.</creator><creator>Duong, K. D.</creator><creator>Nguyen, H. B.</creator><creator>Nguyen, N. L.</creator><creator>Fox, G. J.</creator><creator>Nguyen, N. V.</creator><creator>Marks, G. B.</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>International Union against Tuberculosis and Lung Disease (IUATLD)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20200901</creationdate><title>A comparison of digital chest radiography and Xpert® MTB/RIF in active case finding for tuberculosis</title><author>Nguyen, T. B. P. ; Nguyen, T. A. ; Luu, B. K. ; Le, T. T. O. ; Nguyen, V. S. ; Nguyen, K. C. ; Duong, K. D. ; Nguyen, H. B. ; Nguyen, N. L. ; Fox, G. J. ; Nguyen, N. V. ; Marks, G. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-f807c1220dad8dcf74c480332bc132db69b335dbc8e25b3906d8c6c92e25ec303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Chest</topic><topic>Diagnostic</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>Radiographic Image Enhancement</topic><topic>Radiography</topic><topic>Screening</topic><topic>Sensitivity</topic><topic>Sensitivity and Specificity</topic><topic>Sputum</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - diagnostic imaging</topic><topic>Vietnam</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, T. B. P.</creatorcontrib><creatorcontrib>Nguyen, T. A.</creatorcontrib><creatorcontrib>Luu, B. K.</creatorcontrib><creatorcontrib>Le, T. T. O.</creatorcontrib><creatorcontrib>Nguyen, V. S.</creatorcontrib><creatorcontrib>Nguyen, K. C.</creatorcontrib><creatorcontrib>Duong, K. D.</creatorcontrib><creatorcontrib>Nguyen, H. B.</creatorcontrib><creatorcontrib>Nguyen, N. L.</creatorcontrib><creatorcontrib>Fox, G. J.</creatorcontrib><creatorcontrib>Nguyen, N. V.</creatorcontrib><creatorcontrib>Marks, G. B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, T. B. P.</au><au>Nguyen, T. A.</au><au>Luu, B. K.</au><au>Le, T. T. O.</au><au>Nguyen, V. S.</au><au>Nguyen, K. C.</au><au>Duong, K. D.</au><au>Nguyen, H. B.</au><au>Nguyen, N. L.</au><au>Fox, G. J.</au><au>Nguyen, N. V.</au><au>Marks, G. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of digital chest radiography and Xpert® MTB/RIF in active case finding for tuberculosis</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>24</volume><issue>9</issue><spage>934</spage><epage>940</epage><pages>934-940</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>OBJECTIVE: To compare two community screening tests for TB: sputum examination using Xpert® MTB/RIF and chest radiography (CXR).METHOD: Men aged ≥15 years and women aged >45 years living in 96 sub-communes in Ca Mau, Viet Nam, were invited to provide
a single sputum specimen that was tested using Xpert. Participants were also invited to attend a nearby location for digital radiography. Participants whose sputum was Xpert MTB-positive or whose CXR was reported as 'consistent with TB´ were requested to provide two further sputum
specimens for culture. The sensitivities of the two tests for detecting TB (defined as sputum culture-positive for Mycobacterium tuberculosis) were compared.RESULTS: There were 72 985 eligible participants, of whom 57 597 (78.9%) participated in Xpert screening,
12 752 (17.5%) had CXR and 11 235 (15.4%) had both tests. We estimated that there were 59 cases of TB, of whom 20 were Xpert MTB-positive (programmatic sensitivity 34.0%) and 47 had CXR reported as 'consistent with TB´ (sensitivity 80.0%, P < 0.0001).CONCLUSION:
In community-wide screening for TB, CXR is more sensitive than a single spontaneously expectorated sputum sample tested using Xpert, but it has a substantially lower participation rate.</abstract><cop>France</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>33156761</pmid><doi>10.5588/ijtld.19.0764</doi><tpages>7</tpages></addata></record> |
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| ispartof | The international journal of tuberculosis and lung disease, 2020-09, Vol.24 (9), p.934-940 |
| issn | 1027-3719 1815-7920 |
| language | eng |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Chest Diagnostic Female Humans Male Middle Aged Mycobacterium tuberculosis Radiographic Image Enhancement Radiography Screening Sensitivity Sensitivity and Specificity Sputum Tuberculosis Tuberculosis, Pulmonary - diagnostic imaging Vietnam |
| title | A comparison of digital chest radiography and Xpert® MTB/RIF in active case finding for tuberculosis |
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