Molybdenum disulfide nanomaterial sensor-based detection of breast cancer microRNA
In this study, we sought to establish a rapid, simple, highly sensitive, and highly specific fluorescence sensor for the detection of breast cancer-related microRNA (miRNA) based on the novel nanomaterial known as molybdenum disulfide (MoS2). MoS2, a novel nanomaterial, was added to a fluorescently-...
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| Veröffentlicht in: | Materials express 2020-06, Vol.10 (6), p.915-921 |
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| creator | Zhang, Runling Xia, ChengJing Zhou, Xiaohe Guo, Yanni Li, Weijie |
| description | In this study, we sought to establish a rapid, simple, highly sensitive, and highly specific fluorescence sensor for the detection of breast cancer-related microRNA (miRNA) based on the novel nanomaterial known as molybdenum disulfide (MoS2). MoS2, a novel nanomaterial,
was added to a fluorescently-labeled DNA probe system to construct a fluorescence sensor. Furthermore, non-complementary miRNAs, single-base mismatched miRNAs, and different concentrations of complementary miRNAs were hybridized with the fluorescently-labeled DNA probe. Then, miRNAs were detected
by measuring changes in the fluorescence signals before and after hybridization. The detection was completed within 40 min. The detection limit of complementary miRNA reached pmol/L levels while distinguishing between complementary, non-complementary, and single-base mismatched miRNAs. The
MoS2 fluorescence sensor demonstrated rapid analysis, high sensitivity, and high specificity. Additionally, this established detection method has the potential for application in the rapid detection of breast cancer-related miRNA as a promising cancer detection method. |
| doi_str_mv | 10.1166/mex.2020.1793 |
| format | Article |
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was added to a fluorescently-labeled DNA probe system to construct a fluorescence sensor. Furthermore, non-complementary miRNAs, single-base mismatched miRNAs, and different concentrations of complementary miRNAs were hybridized with the fluorescently-labeled DNA probe. Then, miRNAs were detected
by measuring changes in the fluorescence signals before and after hybridization. The detection was completed within 40 min. The detection limit of complementary miRNA reached pmol/L levels while distinguishing between complementary, non-complementary, and single-base mismatched miRNAs. The
MoS2 fluorescence sensor demonstrated rapid analysis, high sensitivity, and high specificity. Additionally, this established detection method has the potential for application in the rapid detection of breast cancer-related miRNA as a promising cancer detection method.</description><identifier>ISSN: 2158-5849</identifier><identifier>EISSN: 2158-5857</identifier><identifier>DOI: 10.1166/mex.2020.1793</identifier><language>eng</language><publisher>26650 The Old Road, Suite 208, Valencia, California 91381-0751, USA: American Scientific Publishers</publisher><subject>Breast Cancer ; Fluorescence ; Fluorescence Sensor ; MicroRNAs ; Mirna ; Molybdenum ; Molybdenum Disulfide ; Nanomaterials ; Ribonucleic acid ; RNA ; Sensitivity analysis ; Sensors</subject><ispartof>Materials express, 2020-06, Vol.10 (6), p.915-921</ispartof><rights>Copyright American Scientific Publishers Jun 2020</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-be9d511d672ed22682aaa865d9bbe5502d8c778c7b9ea0c5d30d72dae4dd72163</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>288,314,778,782,27911,27912</link.rule.ids></links><search><creatorcontrib>Zhang, Runling</creatorcontrib><creatorcontrib>Xia, ChengJing</creatorcontrib><creatorcontrib>Zhou, Xiaohe</creatorcontrib><creatorcontrib>Guo, Yanni</creatorcontrib><creatorcontrib>Li, Weijie</creatorcontrib><title>Molybdenum disulfide nanomaterial sensor-based detection of breast cancer microRNA</title><title>Materials express</title><description>In this study, we sought to establish a rapid, simple, highly sensitive, and highly specific fluorescence sensor for the detection of breast cancer-related microRNA (miRNA) based on the novel nanomaterial known as molybdenum disulfide (MoS2). MoS2, a novel nanomaterial,
was added to a fluorescently-labeled DNA probe system to construct a fluorescence sensor. Furthermore, non-complementary miRNAs, single-base mismatched miRNAs, and different concentrations of complementary miRNAs were hybridized with the fluorescently-labeled DNA probe. Then, miRNAs were detected
by measuring changes in the fluorescence signals before and after hybridization. The detection was completed within 40 min. The detection limit of complementary miRNA reached pmol/L levels while distinguishing between complementary, non-complementary, and single-base mismatched miRNAs. The
MoS2 fluorescence sensor demonstrated rapid analysis, high sensitivity, and high specificity. Additionally, this established detection method has the potential for application in the rapid detection of breast cancer-related miRNA as a promising cancer detection method.</description><subject>Breast Cancer</subject><subject>Fluorescence</subject><subject>Fluorescence Sensor</subject><subject>MicroRNAs</subject><subject>Mirna</subject><subject>Molybdenum</subject><subject>Molybdenum Disulfide</subject><subject>Nanomaterials</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Sensitivity analysis</subject><subject>Sensors</subject><issn>2158-5849</issn><issn>2158-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kF1LwzAUhosoOOYuvS943ZmkTZveCGP4BVNh6HU4bU5HR5vOJBXnrzdxflwZCOckvHlOeKLonJI5pXl-2eP7nBHmT0WZHkUTRrlIuODF8W-flafRzNot8YtngopsEq0fhm5fKdRjH6vWjl3TKow16KEHh6aFLrao7WCSCiyqWKHD2rWDjocmrgyCdXENukYT921thvXj4iw6aaCzOPuu0-jl5vp5eZesnm7vl4tVUqcldUmFpeKUqrxgqBjLBQMAkXNVVhVyTpgSdVH4XZUIpOYqJapgCjBTvtI8nUYXB-7ODK8jWie3w2i0HykZLzhjIuOZTyWHlP-ctQYbuTNtD2YvKZHBnPTmZDAngzmffzzkW71B7eAP2tYS7E4GmcGlfKNE5-ElJYLkkqYZlwobGDsnHRi5-ZCWlh549Q8w0Ho8zCZfi_40ngfGhZsy_QQDP49O</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Zhang, Runling</creator><creator>Xia, ChengJing</creator><creator>Zhou, Xiaohe</creator><creator>Guo, Yanni</creator><creator>Li, Weijie</creator><general>American Scientific Publishers</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20200601</creationdate><title>Molybdenum disulfide nanomaterial sensor-based detection of breast cancer microRNA</title><author>Zhang, Runling ; Xia, ChengJing ; Zhou, Xiaohe ; Guo, Yanni ; Li, Weijie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-be9d511d672ed22682aaa865d9bbe5502d8c778c7b9ea0c5d30d72dae4dd72163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Breast Cancer</topic><topic>Fluorescence</topic><topic>Fluorescence Sensor</topic><topic>MicroRNAs</topic><topic>Mirna</topic><topic>Molybdenum</topic><topic>Molybdenum Disulfide</topic><topic>Nanomaterials</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Sensitivity analysis</topic><topic>Sensors</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Runling</creatorcontrib><creatorcontrib>Xia, ChengJing</creatorcontrib><creatorcontrib>Zhou, Xiaohe</creatorcontrib><creatorcontrib>Guo, Yanni</creatorcontrib><creatorcontrib>Li, Weijie</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Materials express</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Runling</au><au>Xia, ChengJing</au><au>Zhou, Xiaohe</au><au>Guo, Yanni</au><au>Li, Weijie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molybdenum disulfide nanomaterial sensor-based detection of breast cancer microRNA</atitle><jtitle>Materials express</jtitle><date>2020-06-01</date><risdate>2020</risdate><volume>10</volume><issue>6</issue><spage>915</spage><epage>921</epage><pages>915-921</pages><issn>2158-5849</issn><eissn>2158-5857</eissn><abstract>In this study, we sought to establish a rapid, simple, highly sensitive, and highly specific fluorescence sensor for the detection of breast cancer-related microRNA (miRNA) based on the novel nanomaterial known as molybdenum disulfide (MoS2). MoS2, a novel nanomaterial,
was added to a fluorescently-labeled DNA probe system to construct a fluorescence sensor. Furthermore, non-complementary miRNAs, single-base mismatched miRNAs, and different concentrations of complementary miRNAs were hybridized with the fluorescently-labeled DNA probe. Then, miRNAs were detected
by measuring changes in the fluorescence signals before and after hybridization. The detection was completed within 40 min. The detection limit of complementary miRNA reached pmol/L levels while distinguishing between complementary, non-complementary, and single-base mismatched miRNAs. The
MoS2 fluorescence sensor demonstrated rapid analysis, high sensitivity, and high specificity. Additionally, this established detection method has the potential for application in the rapid detection of breast cancer-related miRNA as a promising cancer detection method.</abstract><cop>26650 The Old Road, Suite 208, Valencia, California 91381-0751, USA</cop><pub>American Scientific Publishers</pub><doi>10.1166/mex.2020.1793</doi><tpages>7</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; IngentaConnect Free/Open Access Journals |
| subjects | Breast Cancer Fluorescence Fluorescence Sensor MicroRNAs Mirna Molybdenum Molybdenum Disulfide Nanomaterials Ribonucleic acid RNA Sensitivity analysis Sensors |
| title | Molybdenum disulfide nanomaterial sensor-based detection of breast cancer microRNA |
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