DETERMINATION OF SOME SELECTED PHARMACEUTICALS IN MARINE BIOTA: A CASE STUDY IN THE ISTANBUL METROPOLITAN AREA, TURKEY

This paper presents data on eleven pharmaceuticals of different classes (nonsteroidal anti-inflammatory drugs, blood lipid regulators, antiepileptics and hormones) in biota (mussels, macroalgae, fish muscle tissue) from the Golden Horn Estuary, Turkey. An ultrasonic extraction method was used to extract pharmaceuticals from the biota. The solid-phase extraction (SPE) method was used for cleanup. High-performance liquid chromatography (HPLC) with a DAD detector was used to quantify the pharmaceuticals. All target compounds were detected in at least one of the samples. Gemfibrozil (56-9135 ng/g) was the most frequently detected compound in all biota samples. Five pharmaceuticals were detected in the macroalgae samples at a maximum concentration of 7221 ng/g for gemfibrozil. Additionally, nine of the pharmaceutical compounds were detected in several or all of the seven fish species. The highest concentration of 17a-cthinylcstra-diol detected in Mullus barbatus was 1258 ng/g. The concentrations of diclofenac (4694 ng/g), naproxen (1570 ng/g), ibuprofen (5098 ng/g), 17ß-estradiol (2364 ng/g), clofibric acid (1296 ng/g), and gemfibrozil (9135 ng/g) were considerably higher in mussels than in other biota species. The accumulation potential of pharmaceutical compounds was higher in mussels than in other biota species.