Reactions of (1-Bromoethenyl)(diphenyl)phosphine Oxide with NH-, OH-, and SH-Nucleophiles

Reactions of (1-Bromoethenyl)(diphenyl)phosphine Oxide with NH-, OH-, and SH-Nucleophiles

The reactions of (1-bromoethenyl)(diphenyl)phosphine oxide with NH-, OH-, SH-nucleophiles were studied. The reaction of phosphine oxide with alcohols and alkanethiols led to the formation of the corresponding adducts, while in reactions with pyrazole, imidazole and triazole ( E )-(vinyl)(diphenyl)ph...

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Veröffentlicht in:Russian journal of general chemistry 2021-08, Vol.91 (8), p.1494-1498
Hauptverfasser: Ovakimyan, M. Zh, Gasparyan, G. Ts, Poghosyan, A. S., Bichakhchyan, A. S., Derdzyan, L. V., Stepanyan, H. M., Muradyan, R. E.
Format: Artikel
Sprache:eng
Schlagworte:
Adducts
Alcohols
Alkanes
Anticancer properties
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Imidazole
Nucleophiles
Phosphine oxide
Pyrazole
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Zusammenfassung:The reactions of (1-bromoethenyl)(diphenyl)phosphine oxide with NH-, OH-, SH-nucleophiles were studied. The reaction of phosphine oxide with alcohols and alkanethiols led to the formation of the corresponding adducts, while in reactions with pyrazole, imidazole and triazole ( E )-(vinyl)(diphenyl)phosphine oxide 2-(azol-1-yl)-derivatives were formed. Antibacterial and antitumor activity of (1-bromoethenyl)(diphenyl)phosphine oxide and its derivatives was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363221080107