IDDF2021-ABS-0010 A meta-analysis and meta-regression between liver resection and liver transplant within milian criteria

BackgroundHepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and a leading cause of cancer globally. Liver transplantation (LT) confers excellent long-term survival outcomes, but its effectiveness is hampered by the dire shortage of liver allografts. Liver resection (LR) is a promising alternative due to favorable outcomes long-term outcomes. We sought to conduct a meta-analysis to compare the survival outcomes between LT and LR for HCC within the Milan criteria.MethodsMedline and Embase databases were searched for studies comparing survival data after LT and LR for patients with HCC within the MC. A meta-analysis of hazard ratios (HR) was conducted using the DerSimonian and Laird random-effects model to compare the overall survival (OS) and disease-free survival (DFS) between LR and LT for HCC. Meta-regression was conducted with mixed effects and logit transform on proportional data.Results35 studies involving 18421 patients were included in the analysis.The OS (HR: 1.44, 95% CI: 1.14 - 1.81, p