Acute associations between air pollution on premature rupture of membranes in Hefei, China

Numerous studies had focused on the association between air pollution and health outcomes in recent years. However, little evidence is available on associations between air pollutants and premature rupture of membranes (PROM). Therefore, we performed time-series analysis to evaluate the association between PROM and air pollution. The daily average concentrations of PM 2.5 , SO 2 and NO 2 were 54.58 μg/m 3 , 13.06 μg/m 3 and 46.09 μg/m 3 , respectively, and daily maximum 8-h average O 3 concentration was 95.67 μg/m 3 . The strongest effects of SO 2 , NO 2 and O 3 were found in lag4, lag06 and lag09, and an increase of 10 μg/m 3 in SO 2 , NO 2 and O 3 was corresponding to increase in incidence of PROM of 8.74% (95% CI 2.12–15.79%), 3.09% (95% CI 0.64–5.59%) and 1.68% (95% CI 0.28–3.09%), respectively. There were no significant effects of PM 2.5 on PROM. Season-specific analyses found that the effects of PM 2.5 , SO 2 and O 3 on PROM were more obvious in cold season, but the statistically significant effect of NO 2 was observed in warm season. We also found the modifying effects by maternal age on PROM, and we found that the effects of SO 2 and NO 2 on PROM were higher among younger mothers (