Synthesis and Biological Activity of Aliphatic Diesters of Glycyldiethanolamine
This study is devoted to the synthesis of a number of glycine derivatives based on aliphatic diesters of diethanolamine, varying in the length of the hydrocarbon radicals, having potential antibacterial activity. A simple and universal scheme is developed, which makes it possible to form a series of...
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| Veröffentlicht in: | Moscow University chemistry bulletin 2021-07, Vol.76 (4), p.253-258 |
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| container_title | Moscow University chemistry bulletin |
| container_volume | 76 |
| creator | Filatova, S. M. Kuzmina, Yu. E. Korotkin, M. D. Solotareva, M. S. Budanova, U. A. Sebyakin, Yu. L. |
| description | This study is devoted to the synthesis of a number of glycine derivatives based on aliphatic diesters of diethanolamine, varying in the length of the hydrocarbon radicals, having potential antibacterial activity. A simple and universal scheme is developed, which makes it possible to form a series of samples in preparative quantities required for biological research. It is stated that the alkyl chain length of the amino acid derivatives of the diethanolamine diesters is important for the demonstrated level of antibacterial activity. The best results with gram-positive and gram-negative bacteria are obtained for compounds with lipophilic chain lengths of the C8 and C10 carbon atoms. |
| doi_str_mv | 10.3103/S0027131421040040 |
| format | Article |
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The best results with gram-positive and gram-negative bacteria are obtained for compounds with lipophilic chain lengths of the C8 and C10 carbon atoms.</description><identifier>ISSN: 0027-1314</identifier><identifier>EISSN: 1935-0260</identifier><identifier>DOI: 10.3103/S0027131421040040</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Aliphatic compounds ; Amino acids ; Biological activity ; Chains ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Diesters ; Diethanolamine ; Glycine ; Synthesis</subject><ispartof>Moscow University chemistry bulletin, 2021-07, Vol.76 (4), p.253-258</ispartof><rights>Allerton Press, Inc. 2021. ISSN 0027-1314, Moscow University Chemistry Bulletin, 2021, Vol. 76, No. 4, pp. 253–258. © Allerton Press, Inc., 2021. 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The best results with gram-positive and gram-negative bacteria are obtained for compounds with lipophilic chain lengths of the C8 and C10 carbon atoms.</description><subject>Aliphatic compounds</subject><subject>Amino acids</subject><subject>Biological activity</subject><subject>Chains</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Diesters</subject><subject>Diethanolamine</subject><subject>Glycine</subject><subject>Synthesis</subject><issn>0027-1314</issn><issn>1935-0260</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1UEtLw0AQXkTBWv0B3gKeo7PPdI-1ahUKPVTPYbLdtFvSbN3dCvn3JlTwIMLAwHyv4SPklsI9p8AfVgCsoJwKRkFAP2dkRDWXOTAF52Q0wPmAX5KrGHcAUjFejMhy1bVpa6OLGbbr7NH5xm-cwSabmuS-XOoyX2fTxh22mJzJnpyNyYY4XOdNZ7pm7WzaYusb3LvWXpOLGptob372mHy8PL_PXvPFcv42my5yw4RKuZBGskJXKAXYycRogwaoXVPFDWq0WAlqC1rVgKg1FRUvjGYSbK0RmRF8TO5OvofgP4_9T-XOH0PbR5ZMKl5oUFz1LHpimeBjDLYuD8HtMXQlhXLorfzTW69hJ03sue3Ghl_n_0Xfn0RvSg</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Filatova, S. 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| ispartof | Moscow University chemistry bulletin, 2021-07, Vol.76 (4), p.253-258 |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Aliphatic compounds Amino acids Biological activity Chains Chemistry Chemistry and Materials Science Chemistry/Food Science Diesters Diethanolamine Glycine Synthesis |
| title | Synthesis and Biological Activity of Aliphatic Diesters of Glycyldiethanolamine |
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